Sildenafil Impurity 256 CAS 1027192-9-2
| CAS No. | 1027192-9-2 |
| Molecular Formula | C22H28N6O3 |
| Molecular Weight | 424.50 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Sildenafil Impurity 256 (CAS 1027192-9-2), a pharmacopoeial impurity reference standard (molecular formula C22H28N6O3, MW 424.50 g/mol) used for the identification and quantification of trace impurities in APIs.
Sildenafil Impurity 256 (C22H28N6O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C22H28N6O3 |
| Molecular Weight | 424.50 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 6 |
Related Sildenafil Standards
- Sildenafil Impurity 255 (CAS CATO-C4X-1128255)
- Sildenafil Impurity 86 (CAS CATO-C4X-112886)
- Sildenafil Impurity 102 (CAS CATO-C4X-1128102)
- Sildenafil Impurity 16 (CAS 1971915-89-5)
- Sildenafil Impurity 282 (CAS CATO-C4X-1128282)
- Sildenafil Impurity 98 (CAS CATO-C4X-112898)
- Sildenafil Impurity 94 (CAS CATO-C4X-112894)
- Sildenafil Impurity N58 (CAS 358388-58-6)
Recommended Standards
- 6-((2,2-Diphenylethyl)amino)-9-(tetrahydro-2H-pyran-2-yl)-9H-purine-2-carbonitrile (CAS 264608-17-5)
- Desethyl Carbodenafil (CAS 1027192-92-2)
- 4-(5-(4-Methylpiperazin-1-yl)-1H,1'H-[2,5'-bibenzo[d]imidazol]-2'-yl)phenol (CAS 23491-44-3)
- H-Gly-Pro-Arg-Pro-NH? (CAS 126047-75-4)
- Haloperidol Impurity 11 (CAS 75478-79-4)
- Cytarabine Impurity 26 (CAS CATO-C4X-200526)
- Salbutamol Impurity 129 (CAS 18910-69-5)
- Cheilanthifoline (CAS 483-44-3)
- 4-(5-(1-Aminoethyl)-4-methylpyridin-2-yl)piperazine-1-carbaldehyde (CAS 1355214-35-5)
- Methyl 2-cyclooctylideneacetate (CAS 99035-18-4)
- N-(4-Amino-2-methylphenyl)-3-methylbenzamide (CAS 926194-81-2)
- 2-(3-Acetylphenyl)isonicotinic acid (CAS 1262005-25-3)
- (S)-2-(2-fluoro-6-(trifluoromethyl)phenyl)pyrrolidine (CAS 1213378-49-4)
- (D-Tyr1,N-Me-Phe3)-Neuropeptide FF (H-4752.0001) (CAS 145274-93-7)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com