Rabeprazole EP Impurity E CAS 102804-77-3
| CAS No. | 102804-77-3 |
| Molecular Formula | C15H15N3O2S |
| Molecular Weight | 301.36 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Rabeprazole EP Impurity E (CAS 102804-77-3, C15H15N3O2S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Rabeprazole EP Impurity E (C15H15N3O2S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 301.36 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Rabeprazole EP Impurity E meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H15N3O2S |
| Molecular Weight | 301.36 g/mol |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Rabeprazole Standards
- Rabeprazole EP Impurity H(Lansoprazole EP Impurity F) (CAS 168167-42-8)
- Rabeprazole EP Impurity G (CAS 102804-82-0)
- Rabeprazole 4-Methylthio Analog (CAS 99487-86-2)
- Rabeprazole RC 6 (CAS 841200-42-8)
- Rabeprazole 4-Chloro Analog Sulfone (CAS 1159977-27-1)
- Rabeprazole Impurity 7 (CAS 117976-91-7)
- Rabeprazole Impurity N1 (CAS 1163685-30-0)
- Rabeprazole Impurity 25 (CAS 1286104-27-5)
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