2',4',5',6'-Tetrahydrospiro[cyclopropane-1,7'-pyrazolo[4,3-c]pyridine] hydrochloride CAS 1028320-39-9
| CAS No. | 1028320-39-9 |
| Molecular Formula | C8H11N3 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
2',4',5',6'-Tetrahydrospiro[cyclopropane-1,7'-pyrazolo[4,3-c]pyridine] hydrochloride (CAS 1028320-39-9) is a high-purity analytical reference standard with the molecular formula C8H11N3HCl and a molecular weight of 185.66 g/mol.
The molecular framework of 2',4',5',6'-Tetrahydrospiro[cyclopropane-1,7'-pyrazolo[4,3-c]pyridine] hydrochloride (C8H11N3HCl) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), 2',4',5',6'-Tetrahydrospiro[cyclopropane-1,7'-pyrazolo[4,3-c]pyridine] hydrochloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H11N3 HCl |
| Molecular Weight | 185.66 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Tetrahydrospiro Standards
- 2',3',4',9'-Tetrahydrospiro[cyclohexane-1,1'-pyrido[3,4-b]indole]-3'-carboxylic acid (CAS 100068-46-0)
- 2',3',5',6'-Tetrahydrospiro[quinazoline-2(1H),4'-[4H]thiopyran]-4(3H)-one (CAS 1031148-75-0)
- 5-Methyl-1,2,4,5-tetrahydrospiro[benzo[c]azepine-3,1'-cycloheptane] (CAS 1049742-94-0)
- 2-(3,5,6,7-Tetrahydrospiro[imidazo[4,5-c]pyridine-4,4'-piperidin]-1'-yl)ethan-1-amine (CAS 1092292-62-0)
- Methyl 2',3',4',9'-tetrahydrospiro[cyclohexane-1,1'-pyrido[3,4-b]indole]-3'-carboxylate (CAS 113247-25-9)
- 2,4,6,7-Tetrahydrospiro[indazole-5,2'-[1,3]dioxolane] hydrochloride (CAS 1160245-61-3)
- 2',3',5',6'-Tetrahydrospiro[indoline-3,4'-pyran]-5-carboxylic acid (CAS 1160247-96-0)
- 2',3',5',6'-Tetrahydrospiro[indene-1,4'-pyran] (CAS 116540-04-6)
Recommended Standards
- 1-{5-methyl-4H,7H-[1,2,3,4]tetrazolo[1,5-a]pyrimidin-6-yl}ethan-1-one (CAS 1803595-71-2)
- Ethyl 2-(1H-pyrrol-1-yl)benzo[d]thiazole-6-carboxylate (CAS 289651-81-6)
- 1-2-3-4-Tetra-O-acetyl-α-L-fucopyranose (CAS 64913-16-2)
- (E)-N-(2-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)amino)ethyl)-2-(2-methoxyphenyl)ethene-1-sulfonamide (CAS 478246-30-9)
- 4-Chloro-2-methyl-6-(trifluoromethyl)-5,6,7,8-tetrahydroquinazoline (CAS 1956325-86-2)
- 1-(2,3-Dimethylpyridin-4-yl)ethanone (CAS 83402-07-7)
- 3-Chloro-4-isopropoxy-5-propoxyphenylboronic acid (CAS 2096339-54-5)
- 2-Bromo-4-methylnicotinonitrile (CAS 65996-02-3)
- 1-Iodo-2,3,5-trimethylbenzene (CAS 31054-00-9)
- Peptide Fmoc-Thi-Thi-OH (CAS CATO-CPTD788552)
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