4,5-Difluoro-2-methylbenzoyl chloride CAS 1030012-21-5
| CAS No. | 1030012-21-5 |
| Molecular Formula | C8H5ClF2O |
| Molecular Weight | 190.57 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4,5-Difluoro-2-methylbenzoyl chloride (CAS 1030012-21-5) is a high-purity analytical reference standard with the molecular formula C8H5ClF2O and a molecular weight of 190.57 g/mol.
Owing to a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system, 4,5-Difluoro-2-methylbenzoyl chloride is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 190.57 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4,5-Difluoro-2-methylbenzoyl chloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H5ClF2O |
| Molecular Weight | 190.57 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | F/Cl-containing |
Related Difluoro Standards
- 2,5-Difluoro-4-methylbenzoyl chloride (CAS 103877-56-1)
- 3,5-Difluoro-4-methylbenzoyl chloride (CAS 103877-74-3)
- 2,4-Difluoro-3-methylbenzoyl chloride (CAS 112857-70-2)
- 2,4-Difluoro-5-methylbenzoyl chloride (CAS 1263376-87-9)
- 3,5-Difluoro-2-methylbenzoyl chloride (CAS 1803782-65-1)
- 2,4-Difluoro-6-methylbenzoyl chloride (CAS 1803813-12-8)
- 3,6-Difluoro-2-methylbenzoyl chloride (CAS 1803825-79-7)
- 2,3-Difluoro-5-methylbenzoyl chloride (CAS 1804417-80-8)
Recommended Standards
- 4'-Chloro-2',6'-difluoroacetophenone (CAS 1017777-45-5)
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- 2-Amino-3-chloro-4-fluoronitrobenzene 2-chloro-3-fluoro-6-nitroaniline 948014-34-4 AS04486 (CAS 948014-34-4)
- Methyl 3-chloro-6-fluoropyrazine-2-carboxylate (CAS 356783-54-5)
- Benzyl (2,5-dimethyloxazol-4-yl)carbamate (CAS 32512-40-6)
- 7-Methyl-2-(4-nitrophenyl)imidazo[1,2-a]pyridine-3-carbaldehyde (CAS 31521-98-9)
- 4-Iodo-3-methoxy-2-(trifluoromethyl)pyridine (CAS 1227577-15-2)
- 3-[(4-Chlorophenyl)sulfanyl]-2-phenylquinoline (CAS 338391-98-3)
- Pimodivir (CAS 1629869-44-8)
- 1-Bromo-4-(2-Cbz-amino)vinylbenzene (CAS 1228957-12-7)
- 6-Chloro-N-(furan-2-ylmethyl)-4-methylbenzo[d]thiazol-2(3h)-imine (CAS 1177346-53-0)
- 4-((5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-yl)thio)butanoic acid (CAS 307341-23-7)
- Methyl 2-chloro-5-isothiocyanatobenzoate (CAS 91151-68-7)
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