4'-Chloro-2',6'-difluoroacetophenone CAS 1017777-45-5
| CAS No. | 1017777-45-5 |
| Molecular Formula | C8H5ClF2O |
| Molecular Weight | 190.57 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
4'-Chloro-2',6'-difluoroacetophenone (CAS 1017777-45-5), molecular formula C8H5ClF2O and molecular weight 190.57 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4'-Chloro-2',6'-difluoroacetophenone (C8H5ClF2O) is characterized by a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
CATO manufactures 4'-Chloro-2',6'-difluoroacetophenone under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C8H5ClF2O |
| Molecular Weight | 190.57 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- 1-(2-Chloro-4,5-difluorophenyl)ethanone (CAS 121872-94-4)
- 1-(4-Chloro-3,5-difluorophenyl)ethan-1-one (CAS 1256352-85-8)
- 2-(2-Chloro-3,6-difluorophenyl)acetaldehyde (CAS 1256477-62-9)
- 2-(3-Chloro-2,6-difluorophenyl)acetaldehyde (CAS 1256479-70-5)
- 1-(6-Chloro-2,3-difluorophenyl)ethan-1-one (CAS 1373920-86-5)
- 1-(3-Chloro-2,4-difluorophenyl)ethanone (CAS 154258-06-7)
- 5-Chloro-2-(difluoromethyl)benzaldehyde (CAS 1554368-81-8)
- 6-Chloro-2,4-difluoro-3-methylbenzaldehyde (CAS 1706435-05-3)
Recommended Standards
- N,N-Dibutyl-N-(difluoromethyl)butan-1-aminium chloride (CAS 1004517-48-9)
- 4,5-Difluoro-2-methylbenzoyl chloride (CAS 1030012-21-5)
- 2-Amino-3-chloro-4-fluoronitrobenzene 2-chloro-3-fluoro-6-nitroaniline 948014-34-4 AS04486 (CAS 948014-34-4)
- 2,5-Difluoro-4-methylbenzoyl chloride (CAS 103877-56-1)
- [S(R)]-N-[(R)-[3,5-Bis(1,1-dimethylethyl)-4-methoxyphenyl][2-(dicyclohexylphosphino)phenyl]methyl]-N,2-dimethyl-2-propanesulfinamide (CAS 2565792-49-4)
- (S)-2-((tert-butoxycarbonyl)amino)-3-(6-fluoro-1H-indol-3-yl)propanoic acid (CAS 1234870-95-1)
- Seladelpar (CAS 851528-79-5)
- 2,3-Difluoro-5-nitrobenzyl chloride (CAS 1805063-70-0)
- n5-[3-(methylsulfanyl)phenyl]pyridine-2,5-diamine (CAS 1018523-30-2)
- 3-(Methylsulfinyl)cyclohexan-1-ol (CAS 2138126-09-5)
- 2-(Pyrimidin-2-yl)propanoic acid (CAS 819850-16-3)
- (R)-2-amino-N-(2-(piperidin-1-yl)ethyl)propanamide (CAS 1306860-93-4)
- 16-alfa-Hydroxy Progesterone (CAS 438-07-3)
- Semaglutide impurity 63 (CAS CATO-C4X-222663)
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