Clofarabine Impurity 7 CAS 10310-21-1
| CAS No. | 10310-21-1 |
| Molecular Formula | C5H4ClN5 |
| Molecular Weight | 169.57 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Clofarabine Impurity 7 (CAS 10310-21-1) is a certified pharmaceutical impurity reference standard with the molecular formula C5H4ClN5 and a molecular weight of 169.57 g/mol.
The molecular framework of Clofarabine Impurity 7 (C5H4ClN5) is characterized by a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Clofarabine Impurity 7 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C5H4ClN5 |
| Molecular Weight | 169.57 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1959 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related Clofarabine Standards
- Clofarabine Impurity 13 (CAS 40928-86-7)
- Clofarabine Impurity 2 (CAS 1334337-31-3)
- Clofarabine Impurity 14 (CAS 1198-46-5)
- Clofarabine Impurity 12 (CAS 5451-40-1)
- Clofarabine Impurity 11 (CAS CATO-C4X-159311)
- Clofarabine Impurity 16 (CAS 899827-82-8)
- Clofarabine Impurity 8 (CAS CATO-C4X-15938)
- Clofarabine (CAS 123318-82-1)
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