Tofacitinib Impurity 220 CAS 1279816-72-6
| CAS No. | 1279816-72-6 |
| Molecular Formula | C6H4ClN3O |
| Molecular Weight | 169.57 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Tofacitinib Impurity 220.
CATO supplies Tofacitinib Impurity 220 (CAS 1279816-72-6), a pharmacopoeial impurity reference standard (molecular formula C6H4ClN3O, MW 169.57 g/mol) used for the identification and quantification of trace impurities in APIs.
Based on its molecular formula C6H4ClN3O, Tofacitinib Impurity 220 contains an amide group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 169.57 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H4ClN3O |
| Molecular Weight | 169.57 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Tofacitinib Standards
- Tofacitinib Impurity 140 (CAS CATO-C4X-1079140)
- Tofacitinib Impurity 206 (CAS CATO-C4X-1079206)
- Tofacitinib Impurity 127 (CAS 1204176-45-3)
- Tofacitinib Impurity 246 (CAS CATO-C4X-1079246)
- Tofacitinib Impurity 52 (CAS 694495-63-1)
- Tofacitinib Impurity 133 (CAS 10132-07-7)
- Tofacitinib Impurity 82 (CAS 1229041-97-7)
- Tofacitinib Impurity 29 (CAS 90953-01-8)
Recommended Standards
- Cladribine EP Impurity C (CAS 1839-18-5)
- Cabozantinib Impurity G (CAS 26198-19-6)
- Clofarabine Impurity 7 (CAS 10310-21-1)
- 8-Chloro-9H-purin-6-amine (CAS 28128-28-1)
- Blonanserin Impurity 16 (CAS CATO-C4X-111016)
- Uridine Impurity 16 (CAS 945684-11-7)
- Edaravone impurity 48 (CAS 87343-64-4)
- 3,4,4,4-Tetrafluoro-3-(trifluoromethyl)but-1-yne (CAS 24690-53-7)
- Bpoc-Ala-OH (CAS 23631-89-2)
- 4-(1h-Pyrazol-1-yl)butanoic acid (CAS 110525-56-9)
- 2-[(4-Fluorophenyl)amino]ethane-1-thiol (CAS 20295-60-7)
- 1-(3-Fluoro-2-methoxyphenyl)ethan-1-one (CAS 295779-86-1)
- (S)-6-Methoxy-2,3-dihydro-1H-inden-1-amine hydrochloride (CAS 180915-62-2)
- Semaglutide impurity 197 (CAS CATO-C4X-2226197)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com