Duloxetine EP Impurity E HCl CAS 1033719-36-6
| CAS No. | 1033719-36-6 |
| Molecular Formula | C18H19NOS |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Duloxetine EP Impurity E HCl (CAS 1033719-36-6) is a certified pharmaceutical impurity reference standard with the molecular formula C18H19NOSHCl and a molecular weight of 333.87 g/mol.
The molecular framework of Duloxetine EP Impurity E HCl (C18H19NOSHCl) is characterized by a steroid core, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H19NOS HCl |
| Molecular Weight | 333.87 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Duloxetine Standards
- Duloxetine EP Impurity E (CAS 1033803-59-6)
- Duloxetine Impurity 55 (CAS 1045348-04-6)
- Duloxetine Impurity 9 (CAS 110-14-5)
- rac-Duloxetine EP Impurity F HCl (CAS 1104890-90-5)
- Duloxetine EP Impurity B (CAS 116539-55-0)
- Duloxetine Impurity (CAS 116539-57-2)
- Duloxetine (CAS 116539-59-4)
- Duloxetine EP Impurity A (CAS 116539-60-7)
Recommended Standards
- Cefazolin EP Impurity B (CAS 2384108-14-7)
- Mirogabalin Impurity 64 (CAS 1644251-71-7)
- Amorolfine EP Impurity E HCl (trans-Amorolfine HCl) (Mixture of Diastereomers) (CAS CATO-C4X-154212)
- 3-Oxo-3-(3,4,5-triethoxyphenyl)propanenitrile (CAS 267880-91-1)
- N-(Furan-2-yl)-N-(4-nitrobenzyl)acetamide (CAS 62187-54-6)
- N-(3-Bromophenyl)-3-(trifluoromethyl)benzamide (CAS 710310-54-6)
- (1H-Imidazol-1-yl)(naphthalen-2-yl)methanone (CAS 141903-34-6)
- Benzyl (3R,4R)-3-amino-4-methylpiperidine-1-carboxylate (CAS 1451068-71-5)
- 2-(4-Methoxyphenyl)acetyl Chloride (CAS 4693-91-8)
- Peptide Impurity (CAS CATO-CPTD788810)
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