rac-Duloxetine EP Impurity F HCl CAS 1104890-90-5
| CAS No. | 1104890-90-5 |
| Molecular Formula | C18H19NOS. |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of rac-Duloxetine EP Impurity F HCl (C18H19NOS.HCl) is characterized by a steroid core, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
CATO supplies rac-Duloxetine EP Impurity F HCl (CAS 1104890-90-5), a pharmacopoeial impurity reference standard (molecular formula C18H19NOS.HCl, MW 333.87 g/mol) used for the identification and quantification of trace impurities in APIs.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H19NOS. HCl |
| Molecular Weight | 333.87 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related rac Standards
- Duloxetine EP Impurity E HCl (CAS 1033719-36-6)
- Duloxetine EP Impurity E (CAS 1033803-59-6)
- Duloxetine Impurity 55 (CAS 1045348-04-6)
- Duloxetine Impurity 9 (CAS 110-14-5)
- Duloxetine EP Impurity B (CAS 116539-55-0)
- Duloxetine Impurity (CAS 116539-57-2)
- Duloxetine (CAS 116539-59-4)
- Duloxetine EP Impurity A (CAS 116539-60-7)
Recommended Standards
- Baxdrostat Impurity 6 (CAS 1428652-88-3)
- Mesalazine EP Impurity C (CAS 95-55-6)
- Lovastatin Impurity 38 (CAS CATO-C4X-168438)
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- (R)-1-(4-Bromo-3-methylphenyl)ethan-1-ol (CAS 1438382-09-2)
- (3aS, 4aR)-1,3-Dibenzyldihydro-1H-selenolo[3,4-d]imidazole-2,4-(3H,3aH)dione (CAS 61253-80-3)
- Methyl 2-((5-(benzo[d]thiazole-2-carboxamido)-1,3,4-thiadiazol-2-yl)thio)butanoate (CAS 1219844-61-7)
- Dendroaspis Natriuretic Peptide (CAS 255721-52-9)
Why CATO?
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- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com