Diltiazem EP Impurity A HCl CAS 103532-27-0
| CAS No. | 103532-27-0 |
| Molecular Formula | C22H26N2O4S |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Diltiazem EP Impurity A HCl (C22H26N2O4SHCl) is characterized by a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Diltiazem EP Impurity A HCl (CAS 103532-27-0) is a certified pharmaceutical impurity reference standard with the molecular formula C22H26N2O4SHCl and a molecular weight of 450.98 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Diltiazem EP Impurity A HCl meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H26N2O4S HCl |
| Molecular Weight | 450.98 g/mol |
| Purity | >90% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Diltiazem Standards
- Diltiazem EP Impurity A HCl (CAS 111188-71-7(free base))
- Diltiazem D4 (CAS 112259-41-3)
- Diltiazem USP Related Compound H HCl (CAS 115992-91-1(Free Base))
- Diltiazem EP Impurity H HCl (CAS 115992-91-1(free base))
- Diltiazem Impurity 9 (CAS 116050-35-2)
- Diltiazem Impurity 23 (CAS 119009-50-6)
- Diltiazem-d3 Hydrochloride (CAS 1217623-80-7)
- L-Diltiazem (CAS 1217650-51-5)
Recommended Standards
- Roxithromycin EP Impurity B (CAS 214902-82-6)
- Tacrolimus Impurity 37 (CAS CATO-C4X-130037)
- Oclacitinib Impurity 39 (CAS CATO-C4X-301839)
- 2-Hydroxy-2-(3-hydroxyphenyl)acetonitrile (CAS 53313-95-4)
- 2-(3,5-Dibromo-4-hydroxybenzylidene)malononitrile (CAS 26195-44-8)
- trans-2-Aminocyclobutanol (CAS 72320-39-9)
- 3-(2-methoxyethyl)-1-methylthiourea (CAS 81467-03-0)
- n-Cyclopropyl-2-(o-tolylthio)acetamide (CAS 1458214-73-7)
- 5-Cyclohexyl-1,2,4-oxadiazol-3-amine (CAS 1260828-37-2)
- Semaglutide impurity 29 (CAS 110990-08-4)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com