Diltiazem Impurity 9 CAS 116050-35-2
| CAS No. | 116050-35-2 |
| Molecular Formula | C20H22N2O4S |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Diltiazem Impurity 9 (CAS 116050-35-2), a pharmacopoeial impurity reference standard (molecular formula C20H22N2O4SHCl, MW 422.92 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Diltiazem Impurity 9 (C20H22N2O4SHCl) is characterized by a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C20H22N2O4S HCl |
| Molecular Weight | 422.92 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Diltiazem Standards
- Diltiazem EP Impurity A HCl (CAS 103532-27-0)
- Diltiazem EP Impurity A HCl (CAS 111188-71-7(free base))
- Diltiazem D4 (CAS 112259-41-3)
- Diltiazem USP Related Compound H HCl (CAS 115992-91-1(Free Base))
- Diltiazem EP Impurity H HCl (CAS 115992-91-1(free base))
- Diltiazem Impurity 23 (CAS 119009-50-6)
- Diltiazem-d3 Hydrochloride (CAS 1217623-80-7)
- L-Diltiazem (CAS 1217650-51-5)
Recommended Standards
- Atogepant Impurity 52 (CAS CATO-C4X-328552)
- Abiraterone Impurity 56 (CAS 500019-37-4)
- Guaiazulene Impurity 7 (CAS 65757-01-9)
- (3R)-1-(1-(Pyridin-2-yl)ethyl)pyrrolidin-3-ol, 95% (CAS 1289689-31-1)
- 3-[(Ethylamino)sulfonyl]benzoic Acid (CAS 7326-74-1)
- 2-(3-Cyclopropoxy-4-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 944332-71-2)
- 4-(2,5-Dichlorophenyl)-1,2-dihydrophthalazin-1-one (CAS 1098353-57-1)
- 371-42-6 4-FLUOROBENZENE-1-THIOL 4-FLUOROTHIOPHENOL 4-MERCAPTOFLUOROBENZENE 4-fluorobenzenethiol AS04129 P-FLUOROPHENYL MERCAPTAN P-FLUOROTHIOPHENOL (CAS 371-42-6)
- N1-[2-(Dicyclohexylphosphino)phenyl]-N2-(2,4,6-trimethylphenyl)-1,2-ethanediamine (CAS 1450876-98-8)
- Semaglutide Impurity 187 (CAS CATO-C4X-2226187)
Why CATO?
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- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com