2-(hydroxymethyl)-2H-furan-5-one CAS 10374-60-4

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-(hydroxymethyl)-2H-furan-5-one.

2-(hydroxymethyl)-2H-furan-5-one (CAS 10374-60-4) is a high-purity analytical reference standard with the molecular formula C5H6O3 and a molecular weight of 114.10 g/mol.

The molecular framework of 2-(hydroxymethyl)-2H-furan-5-one (C5H6O3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

As a certified reference material (CRM), 2-(hydroxymethyl)-2H-furan-5-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

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