5-Methyl-6-nitro-[1,2,4]triazolo[1,5-a]pyrimidin-7(1H)-one CAS 103778-83-2
| CAS No. | 103778-83-2 |
| Molecular Formula | C6H5N5O3 |
| Molecular Weight | 195.14 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 5-Methyl-6-nitro-[1,2,4]triazolo[1,5-a]pyrimidin-7(1H)-one (C6H5N5O3) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
5-Methyl-6-nitro-[1,2,4]triazolo[1,5-a]pyrimidin-7(1H)-one (CAS 103778-83-2), molecular formula C6H5N5O3 and molecular weight 195.14 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H5N5O3 |
| Molecular Weight | 195.14 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Nitrogen Atoms | 5 |
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Recommended Standards
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- (1R,3S,5R,6R)-6-(trifluoromethyl)-2-azabicyclo[3.1.0]Hexane-3-carboxylic acid (CAS 1212823-10-3)
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- 4-(1-ethyl-1{H}-pyrazol-4-yl)-1-methyl-1{H}-pyrazolo[3,4-{b}]pyridine-3-carboxylic acid (CAS 1354705-96-6)
- (2E)-3-[4-(3-Fluoropropoxy)phenyl]-1-{3-[4-(3-fluoropropoxy)phenyl]-1H-pyrazol-1-yl}prop-2-en-1-one (CAS 477711-08-3)
- 2-(benzyloxy)-4-methylphenol (CAS 1025708-75-1)
- 2-(tributylstannyl)furan (CAS 118486-94-5)
- Calcium cyclohexanebutyrate (CAS 110861-66-0)
- Methyl (E)-6-(3,5-dichlorophenyl)-2-(2-(dimethylamino)vinyl)-5-oxo-5,6-dihydro-1,6-naphthyridine-3-carboxylate (CAS 1374510-80-1)
- 2,4-Dihydroxy-3-fluoro-6-(trifluoromethyl)pyridine (CAS 1228898-43-8)
- Lenvatinib Impurity 118 (CAS CATO-C4X-1140118)
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