Loxoprofen Impurity 57 CAS 10386-81-9
| CAS No. | 10386-81-9 |
| Molecular Formula | C14H16O3 |
| Molecular Weight | 232.28 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Loxoprofen Impurity 57 (CAS 10386-81-9), a pharmacopoeial impurity reference standard (molecular formula C14H16O3, MW 232.28 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Loxoprofen Impurity 57 (C14H16O3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, a polycyclic aromatic system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C14H16O3 |
| Molecular Weight | 232.28 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1959 |
Related Loxoprofen Standards
- Loxoprofen Impurity N12 (CAS 13737-36-5)
- Loxoprofen impurity 89 (CAS CATO-C4X-148889)
- Loxoprofen Impurity 61 (CAS CATO-C4X-148861)
- Loxoprofen Impurity 65 (CAS 89878-71-7)
- Loxoprofen impurity 118 (CAS CATO-C4X-1488118)
- Loxoprofen impurity 119 (CAS CATO-C4X-1488119)
- Loxoprofen impurity 120 (CAS CATO-C4X-1488120)
- Loxoprofen impurity 121 (CAS CATO-C4X-1488121)
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Why CATO?
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