Clofazimine Impurity 11 CAS 74002-27-0
| CAS No. | 74002-27-0 |
| Molecular Formula | C12H9ClN2O2 |
| Molecular Weight | 248.67 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Clofazimine Impurity 11 (C12H9ClN2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a process- or degradation-related impurity, Clofazimine Impurity 11 (CAS 74002-27-0, C12H9ClN2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Clofazimine Impurity 11 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C12H9ClN2O2 |
| Molecular Weight | 248.67 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | ＞95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1978 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Clofazimine Standards
- Clofazimine Impurity 10 (CAS CATO-C4X-207110)
- Clofazimine Impurity 5 (CAS 23008-56-2)
- Clofazimine Impurity 19 (CAS CATO-C4X-207119)
- Clofazimine Impurity 15 (CAS CATO-C4X-207115)
- Clofazimine Impurity 16 (CAS CATO-C4X-207116)
- Clofazimine Impurity 18 (CAS CATO-C4X-207118)
- Clofazimine Impurity 13 (CAS CATO-C4X-207113)
- Clofazimine Impurity 6 (CAS CATO-C4X-20716)
Recommended Standards
- Neratinib Impurity 51 (CAS CATO-C4X-113451)
- 2,3-dihydro-1,4-benzodioxin-2-ylmethanesulfonyl chloride (CAS 1018520-20-1)
- Sorafenib impurity 65 (CAS CATO-C4X-112465)
- 4-(Chlorosulfonyl)phenyl propionate (CAS 1029717-21-2)
- Amikacin EP Impurity A (CAS 50725-24-1)
- Axitinib Impurity 40 (CAS CATO-C4X-107140)
- Fingolimod Dimer Impurity (CAS 2147726-86-9)
- (S)-2-((S)-2,6-Diaminohexanamido)-3-(1H-imidazol-4-yl)propanoic acid (CAS 35170-01-5)
- N-(2,4-dichloro-5-(2-methoxyethoxy)phenyl)-2-((2-(methylamino)-2-oxoethyl)sulfonyl)acetamide (CAS 341964-84-9)
- 4-(4-Fluorophenyl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile (CAS 452923-06-7)
- (4-(Benzyloxy)-3,5-dichlorophenyl)(methyl)sulfane (CAS 2404733-67-9)
- n-Methyl-2-(2-(methylamino)phenyl)acetamide (CAS 188837-41-4)
- 1-(6-Iodo-2H-indazol-2-yl)ethan-1-one (CAS 1305711-39-0)
- Neuropeptide Y (2-36), amide, porcine (CAS 102961-52-4)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com