Lacidipine Impurity N1 (E-Isomer) CAS 103890-69-3
| CAS No. | 103890-69-3 |
| Molecular Formula | C14H16O3 |
| Molecular Weight | 232.28 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Lacidipine Impurity N1 (E-Isomer).
CATO supplies Lacidipine Impurity N1 (E-Isomer) (CAS 103890-69-3), a pharmacopoeial impurity reference standard (molecular formula C14H16O3, MW 232.28 g/mol) used for the identification and quantification of trace impurities in APIs.
Lacidipine Impurity N1 (E-Isomer) (C14H16O3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, a polycyclic aromatic system. It is notably hygroscopic, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H16O3 |
| Molecular Weight | 232.28 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
Related Lacidipine Standards
- Lacidipine Impurity 5 (CAS CATO-C4X-16715)
- Lacidipine Impurity 30 (E-Isomer) (CAS 187947-49-5)
- Lacidipine Impurity 4 (CAS CATO-C4X-16714)
- Lacidipine Impurity 29 (E-Isomer) (CAS 180515-27-9)
- Lacidipine Impurity 2 (CAS 28272-96-0)
- Lacidipine Impurity 20 (CAS CATO-C4X-167120)
- Lacidipine Impurity 19 (CAS CATO-C4X-167119)
- Lacidipine Impurity 10 (CAS CATO-C4X-167110)
Recommended Standards
- Fraxinellone (CAS 28808-62-0)
- Vildagliptin Impurity N27 (CAS 2253194-13-5)
- 1,6-Pyrenediamine (CAS 14923-84-3)
- Boc-D-Orn-OH (CAS 159877-12-0)
- Crizotinib Impurity 54 (CAS CATO-C4X-102554)
- Miconazole EP Impurity G HCl (CAS 909277-71-0（free base）)
- Entacapone Impurity 22 (CAS 857629-78-8)
- (5-Methylisoxazol-4-yl)boronic acid (CAS 1012084-55-7)
- (2-Methyl-2H-indazol-7-yl)boronic acid (CAS 1001907-58-9)
- 4-((1H-tetrazol-1-yl)methyl)-2-methoxyphenol (CAS 281676-62-8)
- 1-Methylbenzo[c]phenanthrene (CAS 4076-39-5)
- Ethyl 4-hydroxy-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylate (CAS 187724-99-8)
- 2-(tert-Butoxy)-4-cyclopropoxy-6-ethylpyridine (CAS 1243474-43-2)
- Peptide Impurity 13 (CAS CATO-CPTD788813)
Why CATO?
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