Entacapone Impurity 22 CAS 857629-78-8
| CAS No. | 857629-78-8 |
| Molecular Formula | C15H17N3O5 |
| Molecular Weight | 319.31 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Entacapone Impurity 22.
Entacapone Impurity 22 (CAS 857629-78-8) is a certified pharmaceutical impurity reference standard with the molecular formula C15H17N3O5 and a molecular weight of 319.31 g/mol.
Entacapone Impurity 22 (C15H17N3O5) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H17N3O5 |
| Molecular Weight | 319.31 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Nitrogen Atoms | 3 |
Related Entacapone Standards
- Entacapone Impurity 21 (CAS 158693-04-0)
- Entacapone Impurity 9 (CAS 146698-91-1)
- Entacapone impurity 19 (CAS CATO-C4X-162919)
- Entacapone Impurity 56 (CAS CATO-C4X-162956)
- Entacapone EP Impurity H (CAS 1150310-15-8)
- Entacapone Impurity 23 (CAS 1185241-19-3)
- Entacapone Impurity 11 (CAS CATO-C4X-162911)
- Entacapone Impurity 10 (CAS CATO-C4X-162910)
Recommended Standards
- Avibactam Impurity 144 (CAS CATO-C4X-1348144)
- Mitomycin impurity 4 (CAS CATO-C4X-17014)
- Amlodipine Impurity 27 (CAS 88150-75-8)
- Piperacillin Sodium EP Impurity G (CAS 63422-71-9)
- Lurbinectedin Impurity 6 (CAS 3054883-63-2)
- Lapatinib Impurity 38 (CAS CATO-C4X-119138)
- Dabrafenib Impurity 14 (CAS CATO-C4X-303314)
- 2-((2-(Acryloyloxy)ethoxy)carbonyl)cyclohexane-1-carboxylic acid (CAS 57043-35-3)
- Budesonide Impurity 61 (CAS 131711-17-6)
- 2-tert-Butyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (CAS 1188335-77-4)
- Dexmedetomidine Impurity 94 (CAS CATO-C4X-123094)
- Trans-4-((4-ethylisoquinolin-5-yl)oxy)cyclohexanamine (CAS 651308-52-0)
- 90937-05-6 Angiotensin II, 4-amino-phe(6)- Angiotensin II, 5-L-isoleucine-6-(4-amino-L-phenylalanine)- 6-(4-Amino-phe)-angiotensin II p-Aminophenylalanine(6)-angiotensin II Angiotensin II, 4-aminophenylalanine(6)- Pap-angiotensin II (CAS 90937-05-6)
- Semaglutide impurity 267 (CAS CATO-C4X-2226267)
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