Hexamidine EP Impurity A HCl CAS 104236-65-9
| CAS No. | 104236-65-9 |
| Molecular Formula | C20H25N3O3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 391.90 g/mol gives Hexamidine EP Impurity A HCl distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Hexamidine EP Impurity A HCl (CAS 104236-65-9), a pharmacopoeial impurity reference standard (molecular formula C20H25N3O3HCl, MW 391.90 g/mol) used for the identification and quantification of trace impurities in APIs.
Hexamidine EP Impurity A HCl (C20H25N3O3HCl) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H25N3O3 HCl |
| Molecular Weight | 391.90 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Hexamidine Standards
Recommended Standards
- Neratinib Impurity 5 (CAS CATO-C4X-11345)
- Trelagliptin Impurity 16 (CAS CATO-C4X-104616)
- Betamethasone Impurity 76 (CAS 5534-01-0)
- 3-Bromo-5-methylimidazo[1,2-a]pyridine (CAS 5857-47-6)
- Finerenone Impurity 139 (CAS CATO-C4X-2880139)
- 2-(2-Chloro-4-fluorophenoxy)propanohydrazide 588677-35-4 6184AE C9H10ClFN2O2 (CAS 588677-35-4)
- 5-(Piperidin-4-yl)-1,3,4-oxadiazol-2(3H)-one hydrochloride (CAS 1046079-35-9)
- 5-[(pyrrolidin-1-yl)methyl]pyridin-2-amine (CAS 913573-02-1)
- N-Methyl-1,2,4-thiadiazol-5-amine (CAS 100703-97-7)
- Insulin Degludec Impurity 24 (CAS CATO-C4X-215724)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com