Neratinib Impurity 5 CAS CATO-C4X-11345
| CAS No. | CATO-C4X-11345 |
| Molecular Formula | C26H20ClN5O6 |
| Molecular Weight | 533.92 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO supplies Neratinib Impurity 5 (CAS CATO-C4X-11345), a pharmacopoeial impurity reference standard (molecular formula C26H20ClN5O6, MW 533.92 g/mol) used for the identification and quantification of trace impurities in APIs.
Neratinib Impurity 5 (C26H20ClN5O6) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), Neratinib Impurity 5 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C26H20ClN5O6 |
| Molecular Weight | 533.92 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 19.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related Neratinib Standards
- Neratinib Impurity 21 (CAS 1144516-15-3)
- Neratinib Impurity 13 (CAS 1144516-21-1)
- Neratinib Impurity 7 (CAS 915788-27-1)
- Neratinib Impurity 17 (CAS 1144516-19-7)
- Neratinib Impurity 54 (CAS CATO-C4X-113454)
- Neratinib Impurity 10 (CAS 1144516-13-1)
- Neratinib Impurity 14 (CAS 1144516-14-2)
- Neratinib Impurity 62 (CAS CATO-C4X-113462)
Recommended Standards
- Indomethacin acyl-β-D-glucuronide (CAS 75523-11-4)
- 1,3-Bis(5-(trimethylstannyl)thiophen-2-yl)propane (CAS 1679325-61-1)
- Bis(4-tridecylphenyl)amine (CAS 65235-18-9)
- N-(2-Chloro-5-(trifluoromethyl)phenyl)-2-((4-(4-ethoxyphenyl)-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 477330-00-0)
- Rimegepant Impurity 49 (CAS CATO-C4X-248749)
- Axitinib Impurity 86 (CAS 1824099-80-0)
- Terbinafine Impurity N1 (CAS 83554-69-2)
- N-Methylpyrrolidine-1-sulfonamide (CAS 90810-17-6)
- 8-Amino-6-fluoro-5-methylquinoline-2-carboxylic acid (CAS 1420790-46-0)
- 2-[(1-benzylpiperidin-4-yl)amino]pyridine-3-carboxamide (CAS 1193388-87-2)
- (4-((1,2,2-Trifluorovinyl)oxy)phenyl)boronic acid (CAS 213701-14-5)
- 1-(4-((2-Hydroxyethyl)(isopropyl)amino)piperidin-1-yl)ethanone (CAS 1353966-89-8)
- Methyl 4-(4-methylpiperazino)benzoate (CAS 354813-14-2)
- Biotinyl-S6 Phosphate Acceptor Peptide trifluoroacetate salt (CAS 1815618-12-2)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com