3-(3,4-Difluorophenyl)acryloyl chloride CAS 1043546-64-0
| CAS No. | 1043546-64-0 |
| Molecular Formula | C9H5ClF2O |
| Molecular Weight | 202.59 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 3-(3,4-Difluorophenyl)acryloyl chloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
3-(3,4-Difluorophenyl)acryloyl chloride (CAS 1043546-64-0) is a high-purity analytical reference standard with the molecular formula C9H5ClF2O and a molecular weight of 202.59 g/mol.
3-(3,4-Difluorophenyl)acryloyl chloride (C9H5ClF2O) contains a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C9H5ClF2O |
| Molecular Weight | 202.59 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | F/Cl-containing |
Related Difluorophenyl Standards
- (E)-3-(2,4-Difluorophenyl)acryloyl chloride (CAS 695186-78-8)
- (E)-3-(3,4-Difluorophenyl)acryloyl Chloride (CAS 376608-66-1)
- 1-((3,4-Difluorophenyl)thio)propan-2-one (CAS 1152913-89-7)
- 1-((2,5-Difluorophenyl)thio)propan-2-one (CAS 1152967-45-7)
- 1-((2,4-Difluorophenyl)thio)propan-2-one (CAS 1152970-42-7)
- 1-(3,4-Difluorophenyl)-2-(methylthio)ethan-1-one (CAS 1178315-96-2)
- 1-(2,5-Difluorophenyl)-2-(methylthio)ethan-1-one (CAS 1178832-72-8)
- 1-(2,6-Difluorophenyl)-2-(methylthio)ethan-1-one (CAS 1179725-39-3)
Recommended Standards
- 2-chloro-1-oxido-5-(trifluoromethyl)pyridin-1-ium (CAS 261956-65-4)
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- 7H-Pyrazolo[4,3-d]pyrimidin-7-one, 5-chloro-3-fluoro-1,6-dihydro-1-methyl- (CAS 2445845-24-7)
- 2-Chloro-1-(2,4,6-trihydroxyphenyl)ethanone (CAS 110865-03-7)
- 1-(3-(Cyclopropylmethoxy)phenyl)ethan-1-one (CAS 478163-32-5)
- Thiazolo[4,5-g]isoquinoline (CAS 193342-79-9)
- 6-methoxy-N-(4-methoxyphenyl)-1,3-benzothiazol-2-amine (CAS 112463-77-1)
- 1-Benzyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile (CAS 57712-62-6)
- [(2S)-1-methanesulfonylazetidin-2-yl]methanol (CAS 2165707-07-1)
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- Semaglutide impurity 81 (CAS CATO-C4X-222681)
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