Doxylamine Impurity 6 CAS 105176-70-3
| CAS No. | 105176-70-3 |
| Molecular Formula | C17H22N2O3 |
| Molecular Weight | 302.37 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Doxylamine Impurity 6 (CAS 105176-70-3) is a certified pharmaceutical impurity reference standard with the molecular formula C17H22N2O3 and a molecular weight of 302.37 g/mol.
The molecular framework of Doxylamine Impurity 6 (C17H22N2O3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H22N2O3 |
| Molecular Weight | 302.37 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Nitrogen Atoms | 2 |
Related Doxylamine Standards
- Doxylamine Impurity 5 (CAS 99430-77-0)
- Doxylamine Impurity 7 (CAS 97143-65-2)
- Doxylamine-d<SUB>5</SUB> (CAS 1173020-59-1)
- Doxylamine Impurity 15 (CAS CATO-C4X-178915)
- Doxylamine EP Impurity A (CAS 873407-01-3)
- Doxylamine Hydrogen Succinate EP Impurity A (CAS CATO-C4X-178921)
- (±)-Doxylamine (CAS 469-21-6)
- Doxylamine Impurity 17 (CAS 1221-70-1)
Recommended Standards
- N-Nitroso Cyproheptadine impurity 17 (CAS 3979-11-1)
- Bilastine Impurity 42 (CAS 3112735-82-4)
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- Darolutamide Impurity 35 (CAS 3059851-39-4)
- Apixaban Impurity 8 (CAS 1074549-87-3)
- Mexiletine Impurity 4 (CAS 57204-78-1)
- Vardenafil Impurity 41 (CAS CATO-C4X-101741)
- 4-Chloro-5-((tetrahydro-2H-pyran-4-yl)oxy)quinazolin-7-ol (CAS 379229-72-8)
- N-[(4-Bromophenyl)methyl]cyclopentanamine hydrochloride (CAS 1158544-96-7)
- 5-Ethoxy-4-methyl-1-phenyl-1H-1,2,3-triazole (CAS 92721-95-4)
- 3-Chloro-2,4-difluorophenylmethylsulfone (CAS 1084334-10-0)
- 4-{2-[(3-Methoxybenzyl)oxy]ethyl}piperidinehydrochloride (CAS 1220038-91-4)
- 3-(5-carbamoylthiophen-2-yl)prop-2-enoic acid (CAS 1251478-43-9)
- Semaglutide Impurity 130 (CAS 1188328-40-6)
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