Clevidipine Butyrate impurity 18 CAS 105383-68-4
| CAS No. | 105383-68-4 |
| Molecular Formula | C15H13Cl2NO2 |
| Molecular Weight | 310.18 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Clevidipine Butyrate impurity 18 (C15H13Cl2NO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 310.18 g/mol, it falls into the moderately-high-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a process- or degradation-related impurity, Clevidipine Butyrate impurity 18 (CAS 105383-68-4, C15H13Cl2NO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Clevidipine Butyrate impurity 18 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H13Cl2NO2 |
| Molecular Weight | 310.18 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Clevidipine Standards
- Clevidipine Butyrate impurity 19 (CAS 253597-20-5)
- Clevidipine Impurity C41 (CAS 1898262-46-8)
- Clevidipine butyrate Impurity 15 (CAS 1801167-49-6)
- Clevidipine Impurity 40 (CAS CATO-C4X-101540)
- Clevidipine impurity 38 (CAS 68064-72-2)
- Clevidipine Impurity 35 (CAS CATO-C4X-101535)
- Clevidipine Impurity 41 (CAS CATO-C4X-101541)
- Clevidipine butyrate Impurity 12 (CAS 91854-03-4)
Recommended Standards
- Methyl 2-((2,6-dichloro-3-methylphenyl)amino)benzoate (CAS 3254-79-3)
- Diclofenac Methyl Ester (Aceclofenac EP Impurity B) (CAS 15307-78-5)
- 4-Chloro-2-(3-chlorophenyl)-5-(pyrrolidin-1-yl)pyridazin-3(2H)-one (CAS 320421-70-3)
- 2-(5-Bromo-3-methylpentyl)isoindoline-1,3-dione (CAS 10250-44-9)
- Avanafil Impurity 58 (CAS CATO-C4X-111858)
- Warfarin Impurity 15 (CAS 54288-86-7)
- Troxipide Impurity 15 (CAS CATO-C4X-214815)
- 6-Ethynyl-N-methylpyridazin-3-amine (CAS 1707563-43-6)
- Serotonin Hydrogenoxalate (CAS 3036-16-6)
- Ethyl 6-chloro-4-(4-methoxybenzenesulfonyl)-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylate (CAS 866134-51-2)
- tert-Butyl 4-(3-aminopropyl)piperazine-1-carboxylate (CAS 373608-48-1)
- 2-(3-Ethyl-5-methylisoxazol-4-yl)acetonitrile (CAS 197310-97-7)
- 2,4-Diiodooxazole (CAS 1037597-73-1)
- Semaglutide impurity 229 (CAS CATO-C4X-2226229)
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