Methylprednisolone impurity 87 CAS 105500-05-8
| CAS No. | 105500-05-8 |
| Molecular Formula | C22H30O5 |
| Molecular Weight | 374.47 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Methylprednisolone impurity 87 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Methylprednisolone impurity 87 (CAS 105500-05-8, C22H30O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a flavonoid core, a hydroxyl group, an ether linkage, Methylprednisolone impurity 87 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 374.47 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C22H30O5 |
| Molecular Weight | 374.47 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
Related Methylprednisolone Standards
- Methylprednisolone Impurity 37 (CAS 1746-38-9)
- Methylprednisolone EP Impurity H (CAS 18462-27-6)
- Methylprednisolone impurity 82 (CAS 106502-98-1)
- 6-Alpha-Methylprednisolone (CAS 83-43-2)
- Methylprednisolone EP Impurity F (CAS 1625-39-4)
- Methylprednisolone impurity 95 (CAS 80944-41-8)
- Methylprednisolone Acetate EP Impurity C (CAS 58636-50-3)
- Methylprednisolone EP Impurity A (CAS 91523-05-6)
Recommended Standards
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- Desoximetasone Impurity 1 (CAS 2770242-92-5)
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- Formoterol impurity 116 (CAS CATO-C4X-1525116)
- Flibanserin Impurity 11 (CAS CATO-C4X-198111)
- Lurbinectedin Impurity 20 (CAS 2248127-78-6)
- DiOC5(3) (CAS 53213-81-3)
- Benzyl3-(cyanomethylene)azetidine-1-carboxylate (CAS 1994325-11-9)
- 8-(2,2,2-Trifluoroacetyl)-8-azabicyclo[3.2.1]Octan-3-one (CAS 176910-42-2)
- Methyl 5,5-dimethyl-4-oxooxolane-3-carboxylate (CAS 52704-92-4)
- 5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenecarboxylic acid (CAS 103031-30-7)
- Methyl 2-((2-chloro-5-nitropyrimidin-4-yl)amino)acetate (CAS 859307-58-7)
- Xenopsin-Related Peptide 2 (XP-2) (H-9340.0005) (CAS 117442-29-2)
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