Methylprednisolone impurity 95 CAS 80944-41-8
| CAS No. | 80944-41-8 |
| Molecular Formula | C22H32O5 |
| Molecular Weight | 376.49 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 376.49 g/mol gives Methylprednisolone impurity 95 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Methylprednisolone impurity 95 (CAS 80944-41-8, C22H32O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Methylprednisolone impurity 95 (C22H32O5) contains a flavonoid core, a hydroxyl group, an ether linkage. The carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H32O5 |
| Molecular Weight | 376.49 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1980 |
Related Methylprednisolone Standards
- Methylprednisolone EP Impurity F (CAS 1625-39-4)
- Methylprednisolone Impurity 37 (CAS 1746-38-9)
- Methylprednisolone EP Impurity H (CAS 18462-27-6)
- Methylprednisolone impurity 82 (CAS 106502-98-1)
- Methylprednisolone impurity 87 (CAS 105500-05-8)
- 6-Alpha-Methylprednisolone (CAS 83-43-2)
- Methylprednisolone Acetate EP Impurity C (CAS 58636-50-3)
- Methylprednisolone EP Impurity A (CAS 91523-05-6)
Recommended Standards
- Tiamulin impurity 20 (CAS CATO-C4X-221020)
- Estriol Impurity 14 (CAS 1497406-77-5)
- Fluorocholine (18F) EP Impurity C (CAS 23978-09-8)
- Dehydroxy Indacaterol Impurity (CAS 918968-40-8)
- Adenosine Impurity 21 (CAS 63844-76-8)
- Amiodarone Impurity 18 (CAS 23349-86-2)
- Ergocalciferol EP Impurity D (CAS 469-06-7)
- 3-Cinnamyl-1-(2,4-dichlorobenzyl)-4-hydroxypyridin-2(1H)-one (CAS 477888-19-0)
- 2-Hydroxy-5,7-dimethyl-2,3-dihydro-1H-pyrazolo[1,2-a]pyrazol-4-ium chloride (CAS 1078584-72-1)
- N-(3-bromophenyl)cyclohexanecarboxamide (CAS 452365-99-0)
- 4-Bromo-2-cyano-6-((trifluoromethyl)thio)benzene-1-sulfonyl chloride (CAS 1805119-54-3)
- 1-(4-((4-Ethoxynaphthalen-1-yl)sulfonyl)piperazin-1-yl)ethan-1-one (CAS 941008-51-1)
- 2-(4-Bromo-5-(difluoromethyl)pyridin-2-yl)acetonitrile (CAS 1805311-32-3)
- Integrin Binding Peptide trifluoroacetate salt (CAS 278792-07-7)
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