Atrasentan Impurity 144 CAS 1058349-57-7
| CAS No. | 1058349-57-7 |
| Molecular Formula | C36H52N2O6 |
| Molecular Weight | 608.82 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Atrasentan Impurity 144 (C36H52N2O6) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a process- or degradation-related impurity, Atrasentan Impurity 144 (CAS 1058349-57-7, C36H52N2O6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Atrasentan Impurity 144 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C36H52N2O6 |
| Molecular Weight | 608.82 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Nitrogen Atoms | 2 |
Related Atrasentan Standards
- Atrasentan Impurity 108 (CAS 1059052-13-9)
- Atrasentan Impurity 109 (CAS 1059052-17-3)
- Atrasentan Impurity 134 (CAS 1058349-07-7)
- Atrasentan Impurity 153 (CAS 1058404-03-7)
- Atrasentan Impurity 66 (CAS 1058349-13-5)
- Atrasentan Impurity 67 (CAS 1058350-93-8)
- Atrasentan Impurity 71 (CAS 1058404-10-6)
- Atrasentan Impurity 87 (CAS 1059043-33-2)
Recommended Standards
- N,N'-([4,4'-Bipiperidine]-1,1'-diylbis(ethane-2,1-diyl))bis(acridin-9-amine) (CAS 119643-88-8)
- Azithromycin Impurity 44 (CAS 2365312-76-9)
- Paliperidone Impurity 41 (CAS CATO-C4X-172441)
- Atrasentan Impurity 88 (CAS 1059043-37-6)
- Indapamide Impurity 2 (CAS CATO-C4X-14002)
- Cinitapride Impurity 16 (CAS 86713-16-3)
- Prasugrel EP Impurity F (CAS 947502-66-1)
- 6-Bromo-2,3-dimethoxy-7-methyl-1-propylnaphthalene (CAS 213971-39-2)
- 4-Methyl-3-{[(4-methylphenyl)sulfonyl]amino}benzoic acid (CAS 777897-86-6)
- *Deltamethrin Impurity 6 (CAS 52820-00-5)
- D-Tyr-Pasireotide (CAS CATO-C4X-20086)
- 6-(Dimethylamino)picolinic acid (CAS 30721-88-1)
- 8-Methoxy-2-oxochromane-3-carboxylic acid (CAS 1333150-90-5)
- Semaglutide impurity 272 (CAS CATO-C4X-2226272)
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