Atrasentan Impurity 143 CAS 1058349-56-6
| CAS No. | 1058349-56-6 |
| Molecular Formula | C34H48N2O6 |
| Molecular Weight | 580.77 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Atrasentan Impurity 143 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Atrasentan Impurity 143 (CAS 1058349-56-6, C34H48N2O6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, Atrasentan Impurity 143 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 580.77 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C34H48N2O6 |
| Molecular Weight | 580.77 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Nitrogen Atoms | 2 |
Related Atrasentan Standards
- Atrasentan Impurity 105 (CAS 1059052-12-8)
- Atrasentan Impurity 114 (CAS 1073746-06-1)
- Atrasentan Impurity 133 (CAS 1058349-06-6)
- Atrasentan Impurity 137 (CAS 1058349-12-4)
- Atrasentan Impurity 139 (CAS 1058349-18-0)
- Atrasentan Impurity 145 (CAS 1058350-11-0)
- Atrasentan Impurity 148 (CAS 1058350-27-8)
- Atrasentan Impurity 149 (CAS 1058350-31-4)
Recommended Standards
- Atrasentan Impurity 165 (CAS 1059043-32-1)
- Atrasentan Impurity 166 (CAS 1059043-38-7)
- Tirofiban Impurity 17 (CAS CATO-C4X-125417)
- Atrasentan Impurity 167 (CAS 1059043-40-1)
- Letermovir Impurity 85 (CAS CATO-C4X-291585)
- Darolutamide Impurity 27 (CAS 1297538-27-2)
- Ozanimod Impurity 17 (CAS 58161-38-9)
- 1-(Benzo[b]thiophen-3-yl)propan-2-one (CAS 1131-08-4)
- (S)-2-Amino-N-((1-benzylpiperidin-4-yl)methyl)-3-methylbutanamide (CAS 1353996-84-5)
- 6-(2-Methylphenyl)picolinic acid (CAS 887983-38-2)
- N-(1-(Tetrahydrofuran-3-yl)-1H-pyrazol-4-yl)thiophene-3-carboxamide (CAS 1797086-48-6)
- 3-(Thiophen-2-yl)isoxazol-5-amine (CAS 35113-40-7)
- Fmoc-D-Glu-ODmab (CAS 874486-65-4)
- Semaglutide impurity 233 (CAS CATO-C4X-2226233)
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