Atrasentan Impurity 26 CAS 1058401-84-5
| CAS No. | 1058401-84-5 |
| Molecular Formula | C29H38N2O6 |
| Molecular Weight | 510.63 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Atrasentan Impurity 26 (CAS 1058401-84-5, C29H38N2O6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Atrasentan Impurity 26 (C29H38N2O6) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C29H38N2O6 |
| Molecular Weight | 510.63 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Nitrogen Atoms | 2 |
Related Atrasentan Standards
- Atrasentan Impurity 158 (CAS 2469258-87-3)
- Atrasentan Impurity 159 (2S,3S,4R) (CAS 173864-34-1)
- Atrasentan Impurity 19 (CAS 1058350-29-0)
- Atrasentan Impurity 31 (CAS 1059040-09-3)
- Atrasentan Impurity 6 (CAS 1350240-35-5)
- Atrasentan Impurity 8 (CAS 195510-48-6)
- Atrasentan (CAS 173937-91-2)
- Atrasentan Impurity 197 (CAS CATO-C4X-3347197)
Recommended Standards
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- tert-Butyl (R)-3-(2,5-dimethoxybenzyl)piperazine-1-carboxylate (CAS 1260588-69-9)
- 3-(3-Methyl-1,2,4-oxadiazol-5-yl)cyclobutan-1-one (CAS 1080636-56-1)
- Tau Peptide (304-318) trifluoroacetate salt (CAS 330456-49-0)
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