Triamcinolone Acetonide Impurity 51 CAS 2796-78-3

Purity ≥95%In StockPharmacopoeial Impurity Standards
CAS No.2796-78-3
Molecular FormulaC28H35FO8
Molecular Weight518.57 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Triamcinolone Acetonide Impurity 51 CAS 2796-78-3 chemical structure

Description

Compared with other compounds in its class, the molecular weight of 518.57 g/mol gives Triamcinolone Acetonide Impurity 51 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.

CATO supplies Triamcinolone Acetonide Impurity 51 (CAS 2796-78-3), a pharmacopoeial impurity reference standard (molecular formula C28H35FO8, MW 518.57 g/mol) used for the identification and quantification of trace impurities in APIs.

Triamcinolone Acetonide Impurity 51 (C28H35FO8) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, a polycyclic aromatic system. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

Molecular FormulaC28H35FO8
Molecular Weight518.57 g/mol
AppearancePale yellow to yellow crystalline powder. (slight halide-like odor)
Purity≥95%
StorageStore at room temperature, protect from light, keep sealed and dry
Solubility (reference)Soluble in methanol, acetonitrile, DMSO, water (slightly soluble)
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)11.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1957
Halogen ContentF-containing

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