2-Fluoro-4-(piperidin-3-yloxy)benzonitrile CAS 1063734-68-8
| CAS No. | 1063734-68-8 |
| Molecular Formula | C12H13FN2O |
| Molecular Weight | 220.24 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 2-Fluoro-4-(piperidin-3-yloxy)benzonitrile (C12H13FN2O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
2-Fluoro-4-(piperidin-3-yloxy)benzonitrile (CAS 1063734-68-8), molecular formula C12H13FN2O and molecular weight 220.24 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-Fluoro-4-(piperidin-3-yloxy)benzonitrile meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H13FN2O |
| Molecular Weight | 220.24 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Fluoro Standards
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- 6-Fluoro-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole (CAS 1178903-34-8)
- 6-Fluoro-2-(pyrrolidin-3-yl)isoindolin-1-one (CAS 1206969-88-1)
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- 3-Fluoro-4-(3-hydroxypiperidin-1-yl)benzonitrile (CAS 1247085-74-0)
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Recommended Standards
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- 1-(2-Fluorophenyl)-3-(propan-2-yl)-4,5-dihydro-1H-pyrazol-5-one (CAS 1092295-70-9)
- 5-Carboxy-N-phenyl-2-1H-pyridone-d5 (CAS 1020719-24-7)
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