Methyl (2R,4R)-4-fluoropyrrolidine-2-carboxylate CAS 1064078-37-0
| CAS No. | 1064078-37-0 |
| Molecular Formula | C6H10FNO2 |
| Molecular Weight | 147.15 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Methyl (2R,4R)-4-fluoropyrrolidine-2-carboxylate (C6H10FNO2) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Methyl (2R,4R)-4-fluoropyrrolidine-2-carboxylate (CAS 1064078-37-0) is a high-purity analytical reference standard with the molecular formula C6H10FNO2 and a molecular weight of 147.15 g/mol.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H10FNO2 |
| Molecular Weight | 147.15 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Recommended Standards
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- 6-Fluoroisoquinoline (CAS 1075-11-2)
- (E)-N-(3,4-Dimethoxybenzyl)-3-[4-(3-fluoropropoxy)phenyl]-2-propenamide (CAS 1164464-37-2)
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- 1-[2-(3-Piperidinyl)ethyl]piperidine (CAS 122373-92-6)
- tert-Butyl ((3S,4R)-4-methylpiperidin-3-yl)carbamate (CAS 1821828-53-8)
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- Tirzepatide Impurity 25 X TFA Salt (CAS CATO-C4X-324025)
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