Methyl 6-bromo-7-chloro-4-hydroxy-8-methylquinoline-2-carboxylate CAS 1065074-46-5

Purity 97%+In StockPharmaceutical Standards
CAS No.1065074-46-5
Molecular FormulaC12H9BrClNO3
Molecular Weight330.56 g/mol
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

Methyl 6-bromo-7-chloro-4-hydroxy-8-methylquinoline-2-carboxylate CAS 1065074-46-5 chemical structure

Description

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

CATO supplies Methyl 6-bromo-7-chloro-4-hydroxy-8-methylquinoline-2-carboxylate (CAS 1065074-46-5), a certified reference material (molecular formula C12H9BrClNO3, MW 330.56 g/mol) for analytical method development and quality control.

Methyl 6-bromo-7-chloro-4-hydroxy-8-methylquinoline-2-carboxylate (C12H9BrClNO3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine/bromine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

Molecular FormulaC12H9BrClNO3
Molecular Weight330.56 g/mol
AppearancePale yellow to yellow crystalline powder. (slight halide-like odor, low volatility)
Purity97%+
StorageStore at 2-8°C, protect from light, keep sealed and dry
Solubility (reference)Soluble in chloroform, dichloromethane, ethyl acetate, DMSO
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)8.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1988
Halogen ContentCl/Br-containing
Nitrogen Atoms1

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