Tetrabenazine Impurity 1 CAS 1065193-59-0
| CAS No. | 1065193-59-0 |
| Molecular Formula | C18H27NO3 |
| Molecular Weight | 305.41 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Tetrabenazine Impurity 1 (CAS 1065193-59-0, C18H27NO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Tetrabenazine Impurity 1 (C18H27NO3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C18H27NO3 |
| Molecular Weight | 305.41 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Nitrogen Atoms | 1 |
Related Tetrabenazine Standards
- Tetrabenazine Impurity 31-D3 (CAS CATO-C4X-274831)
- Tetrabenazine Impurity 32-D3 (CAS CATO-C4X-274832)
- Tetrabenazine Impurity C82 (CAS 149183-89-1)
- Tetrabenazine Impurity 48 (CAS 1214267-46-5)
- Tetrabenazine Impurity 8 (CAS 2624055-86-1)
- Tetrabenazine Impurity C1327 (CAS 1556098-48-6)
- Tetrabenazine Impurity C298 (CAS 100322-43-8)
- Tetrabenazine Impurity C49 (CAS 1381929-92-5)
Recommended Standards
- Pentoxyverine Impurity 22 (CAS 13877-99-1)
- Capsaicin (CAS 404-86-4)
- Pentoxyverine impurity 18 (CAS 1421930-96-2)
- (Z)-Capsaicin (CAS 25775-90-0)
- Clopidogrel Impurity 15 (CAS 40412-06-4)
- Tapentadol impurity 7 (CAS 387356-03-8)
- Gemcitabine Impurity 38 (CAS CATO-C4X-137238)
- 1-((1-Methyl-1H-pyrazol-4-yl)methyl)piperidin-3-amine (CAS 1019005-82-3)
- 3-Fluoro-1-propyl-1H-pyrazole-4-carboxylic acid (CAS 1823833-25-5)
- Methyl 4-methyltetrahydro-2H-thiopyran-4-carboxylate (CAS 2107533-33-3)
- Tert-butyl (3-cyanopyridin-2-yl)carbamate (CAS 116799-19-0)
- methyl exo-8-azabicyclo[3.2.1]octane-2-carboxylate (CAS 1408075-58-0)
- 2-(Tetrahydrofuran-3-yl)azetidine hydrochloride (CAS 2138518-99-5)
- Liraglutide Impurity 21 TFA Salt (CAS CATO-C4X-199221)
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