N-(3-Bromo-4-chlorophenyl)nicotinamide CAS 1065483-57-9
| CAS No. | 1065483-57-9 |
| Molecular Formula | C12H8BrClN2O |
| Molecular Weight | 311.56 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
N-(3-Bromo-4-chlorophenyl)nicotinamide (CAS 1065483-57-9) is a high-purity analytical reference standard with the molecular formula C12H8BrClN2O and a molecular weight of 311.56 g/mol.
The molecular framework of N-(3-Bromo-4-chlorophenyl)nicotinamide (C12H8BrClN2O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine/bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), N-(3-Bromo-4-chlorophenyl)nicotinamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H8BrClN2O |
| Molecular Weight | 311.56 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | Cl/Br-containing |
| Nitrogen Atoms | 2 |
Related N Standards
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Recommended Standards
- N-(3-Bromophenyl)-2-chloroisonicotinamide (CAS 1019466-39-7)
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- Ethyl (2-chloro-4-formylphenoxy)acetate (CAS 16231-54-2)
- 1-(Fluoromethyl)-2-methyl-1H-benzo[d]imidazole (CAS 120720-70-9)
- 2-(2-Chloro-4-(chloromethyl)-6-(difluoromethyl)pyridin-3-yl)acetic acid (CAS 1806071-67-9)
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- Semaglutide impurity 23 (CAS CATO-C4X-222623)
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