Famotidine Impurity 23 CAS 106649-95-0
| CAS No. | 106649-95-0 |
| Molecular Formula | C3H8ClN3O2S |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Famotidine Impurity 23.
Famotidine Impurity 23 (CAS 106649-95-0) is a certified pharmaceutical impurity reference standard with the molecular formula C3H8ClN3O2SHCl and a molecular weight of 222.08 g/mol.
Owing to an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, Famotidine Impurity 23 is typically white to off-white crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 222.08 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Famotidine Impurity 23 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C3H8ClN3O2S HCl |
| Molecular Weight | 222.08 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 0.0 |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Famotidine Standards
- Famotidine impurity HCl, >98% (CAS 100599-91-5)
- Famotidine EP Impurity I (CAS 1020719-36-1)
- Famotidine EP Impurity C (CAS 106433-44-7)
- Famotidine EP Impurity H (CAS 106649-96-1)
- Famotidine EP Impurity F (CAS 107880-74-0)
- Famotidine EP Impurity B Dimaleate (CAS 109467-08-5)
- Famotidine impurity 01 (CAS 1185040-73-6)
- Famotidine-13C3 (CAS 1185241-48-8)
Recommended Standards
- Ornidazole Impurity 111 (CAS CATO-C4X-1331111)
- Cefdinir Impurity 70 (CAS CATO-C4X-121070)
- Dronedarone Impurity 32 (CAS CATO-C4X-109232)
- 7-Bromo-6-fluoro-3,4-dihydroisoquinolin-1(2H)-one (CAS 2253789-35-2)
- 2,4-Dichlorobenzyl Alcohol EP Impurity G (CAS 207974-13-8)
- N-tert-Butoxycarbonyl 3,5-Diiodotyramine (CAS 788824-51-1)
- 2-(4-Bromo-3-methylphenyl)benzo[d]oxazol-5-amine (CAS 354561-72-1)
- Ethyl (S)-4,4-dimethylpyrrolidine-2-carboxylate hydrochloride (CAS 1628853-42-8)
- [(4-Methylphenyl)amino]acetic acid (CAS 21911-69-3)
- D-[Ser]8-Liraglutide (CAS CATO-C4X-199238)
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