5-Amino-2-(trifluoromethyl)phenol CAS 106877-47-8
| CAS No. | 106877-47-8 |
| Molecular Formula | C7H6F3NO |
| Molecular Weight | 177.12 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 5-Amino-2-(trifluoromethyl)phenol is closely related to an amide group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
5-Amino-2-(trifluoromethyl)phenol (CAS 106877-47-8), molecular formula C7H6F3NO and molecular weight 177.12 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to an amide group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system, 5-Amino-2-(trifluoromethyl)phenol is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 177.12 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 5-Amino-2-(trifluoromethyl)phenol meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H6F3NO |
| Molecular Weight | 177.12 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Amino Standards
- 2-Amino-3-trifluoromethylphenol (CAS 106877-48-9)
- (3-Amino-2,5,6-trifluorophenyl)methanol (CAS 1296309-57-3)
- 4-Amino-2-(trifluoromethyl)phenol (CAS 1535-76-8)
- 2-Amino-4-(trifluoromethyl)phenol (CAS 454-81-9)
- 3-Amino-5-(trifluoromethyl)phenol (CAS 401-86-5)
- 4-Amino-3-(trifluoromethyl)phenol (CAS 445-04-5)
- 2-amino-6-fluoro-1,3-benzoxazole-5-carbonitrile (CAS 1820603-76-6)
- 2-Amino-6-fluoro-1,3-benzoxazole-7-carbonitrile (CAS 1820648-99-4)
Recommended Standards
- 4-Methoxy-2-(trifluoromethyl)pyridine (CAS 1065103-97-0)
- 4-(Difluoromethoxy)-2-fluoroaniline (CAS 1003865-65-3)
- 2,2,2-Trifluoro-1-(pyridin-2-yl)ethanol (CAS 107040-75-5)
- Dimethyl nitromalonate (CAS 5437-67-2)
- 2-(Pyrrolidin-3-yloxy)pyridine dihydrochloride (CAS 1220039-88-2)
- N-Butyl-2-(methylamino)acetamide hydrochloride (CAS 262300-46-9)
- 2-(Butylthio)acetimidamide (CAS 105324-30-9)
- 1H-imidazo[4,5-f]quinoxalin-2-amine (CAS 118175-25-0)
- 2-(3-(Methoxymethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 675605-91-1)
- N-(5-fluoro-2-methylphenyl)-2-(4-phenylpiperazin-1-yl)acetamide (CAS 763126-53-0)
- Selumetinib Impurity 15 (CAS CATO-C4X-305315)
- 5-([1,1'-Biphenyl]-4-yl)oxazole (CAS 1145-12-6)
- 2-(Hydrazinylmethyl)quinoline (CAS 1016513-69-1)
- Amyloid Precursor Frameshift Mutant C-Terminal Peptide trifluoroacetate salt (CAS 189125-14-2)
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