2-Amino-4-(trifluoromethyl)phenol CAS 454-81-9
| CAS No. | 454-81-9 |
| Molecular Formula | C7H6F3NO |
| Molecular Weight | 177.12 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-Amino-4-(trifluoromethyl)phenol.
2-Amino-4-(trifluoromethyl)phenol (CAS 454-81-9), molecular formula C7H6F3NO and molecular weight 177.12 g/mol, is a CATO reference standard with documented purity and traceability.
Based on its molecular formula C7H6F3NO, 2-Amino-4-(trifluoromethyl)phenol contains an amide group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 177.12 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-Amino-4-(trifluoromethyl)phenol meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H6F3NO |
| Molecular Weight | 177.12 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Amino Standards
- 5-Amino-2-(trifluoromethyl)phenol (CAS 106877-47-8)
- 2-Amino-3-trifluoromethylphenol (CAS 106877-48-9)
- (3-Amino-2,5,6-trifluorophenyl)methanol (CAS 1296309-57-3)
- 4-Amino-2-(trifluoromethyl)phenol (CAS 1535-76-8)
- 3-Amino-5-(trifluoromethyl)phenol (CAS 401-86-5)
- 4-Amino-3-(trifluoromethyl)phenol (CAS 445-04-5)
- 2-amino-6-fluoro-1,3-benzoxazole-5-carbonitrile (CAS 1820603-76-6)
- 2-Amino-6-fluoro-1,3-benzoxazole-7-carbonitrile (CAS 1820648-99-4)
Recommended Standards
- 2,2-Difluoro-1-(5-fluoropyridin-2-yl)ethan-1-ol (CAS 2169580-50-9)
- 2-Hydroxy-3-(trifluoromethyl)aniline (CAS 72534-45-3)
- 2-(Hydroxymethyl)-5-(trifluoromethyl)pyridine (CAS 31181-84-7)
- 2-Methoxy-4-(trifluoromethyl)pyridine (CAS 219715-34-1)
- Isopropyl 2-propoxyacetate (CAS 1121583-62-7)
- (Acetoxymethyl)trifluoroborate (CAS 910377-68-3)
- 5-Methyl-1-propyl-1h-pyrazole-4-sulfonyl chloride (CAS 1006495-95-9)
- 4-Propylchroman-4-amine (CAS 1482901-92-7)
- 2-Amino-5-isopropyl-6-methylpyrimidin-4(1H)-one (CAS 500161-11-5)
- n-(3-Bromo-4-methoxybenzyl)-2-methylpropan-1-amine (CAS 1152927-58-6)
- 4-Methyl-1-phenyl-2-pentanol (CAS 7779-78-4)
- N-(4-Sulfamoylphenyl)isobutyramide (CAS 114841-20-2)
- 5-Ethoxy-1-propyl-1H-indole-3-carbaldehyde (CAS 1134334-43-2)
- Liraglutide Impurity 19 TFA Salt (CAS CATO-C4X-199219)
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