4-Bromo-7-fluoro-2-methylquinoline CAS 1070879-48-9
| CAS No. | 1070879-48-9 |
| Molecular Formula | C10H7BrFN |
| Molecular Weight | 240.07 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-Bromo-7-fluoro-2-methylquinoline.
4-Bromo-7-fluoro-2-methylquinoline (CAS 1070879-48-9) is a high-purity analytical reference standard with the molecular formula C10H7BrFN and a molecular weight of 240.07 g/mol.
4-Bromo-7-fluoro-2-methylquinoline (C10H7BrFN) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/bromine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H7BrFN |
| Molecular Weight | 240.07 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 1 |
Related Bromo Standards
- 4-Bromo-6-fluoro-2-methylquinoline (CAS 1070879-47-8)
- 3-bromo-8-fluoro-2-methylquinoline (CAS 1259519-95-3)
- 1-(2-Bromo-4-fluorophenyl)cyclopropanecarbonitrile (CAS 1314663-80-3)
- 1-(3-Bromo-5-fluorophenyl)cyclopropane-1-carbonitrile (CAS 1314709-94-8)
- 1-(3-BRomo-2-fluorophenyl)cyclopropane-1-carbonitrile (CAS 1314760-03-6)
- 1-(5-Bromo-2-fluorophenyl)cyclopropanecarbonitrile (CAS 1314781-73-1)
- 1-(4-Bromo-3-fluorophenyl)-1H-pyrrole (CAS 1352213-98-9)
- 3-Bromo-8-fluoro-6-methylquinoline (CAS 1352443-19-6)
Recommended Standards
- Crisaborole impurity 161 (CAS CATO-C4X-2021161)
- 2-(Bromomethyl)-7-fluoroquinoline (CAS 127481-98-5)
- Tedizolid Impurity 75 (CAS CATO-C4X-105475)
- Tedizolid Impurity 54 (CAS 380380-64-3)
- 3-(1,3-Benzothiazol-2-yl)-4-(2-methoxyphenyl)but-3-enoic acid (CAS 748786-62-1)
- Methyl 5-bromo-4-fluoro-2-methylbenzoate (CAS 1564624-36-7)
- 1-Oleoylglycerophosphocholine (CAS 3542-29-8)
- 4-Octylphenyl Salicylate (CAS 2512-56-3)
- 2-(1H-Indol-5-yl)-N-methylethanesulfonamide (CAS 98623-50-8)
- (5E)-5-{[4-(cyclohexylsulfanyl)-3-nitrophenyl]methylidene}-2-sulfanylidene-1,3-thiazolidin-4-one (CAS 298215-77-7)
- 4,4'-Oxydibutanenitrile (CAS 176720-03-9)
- 1-Nitro-4-(prop-1-en-1-yl)benzene (CAS 25798-60-1)
- 2-{[5-(propan-2-yl)-1,2-oxazol-3-yl]methoxy}ethan-1-amine (CAS 1120284-77-6)
- Hexapeptide-9 (CAS 885024-94-2)
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