2-(Bromomethyl)-7-fluoroquinoline CAS 127481-98-5
| CAS No. | 127481-98-5 |
| Molecular Formula | C10H7BrFN |
| Molecular Weight | 240.07 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 240.07 g/mol gives 2-(Bromomethyl)-7-fluoroquinoline distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
2-(Bromomethyl)-7-fluoroquinoline (CAS 127481-98-5) is a high-purity analytical reference standard with the molecular formula C10H7BrFN and a molecular weight of 240.07 g/mol.
The molecular framework of 2-(Bromomethyl)-7-fluoroquinoline (C10H7BrFN) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H7BrFN |
| Molecular Weight | 240.07 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 1 |
Related Bromomethyl Standards
- 2-(Bromomethyl)-6-fluoroquinoline (CAS 168083-35-0)
- 2-(Bromomethyl)-5-fluoroquinoline (CAS 346604-39-5)
- 8-(bromomethyl)-5-fluoroquinoline (CAS 88474-21-9)
- 8-(Bromomethyl)-6-fluoroquinoline (CAS 926262-79-5)
- 4-(bromomethyl)furan-2-sulfonamide (CAS 1955520-01-0)
- 2-(Bromomethyl)-5-cyanobenzoic acid (CAS 1261671-00-4)
- 2-(Bromomethyl)benzo[d]oxazole-7-carboxaldehyde (CAS 1803863-22-0)
- 2-(Bromomethyl)benzo[d]oxazole-6-carboxaldehyde (CAS 1806341-78-5)
Recommended Standards
- 3-bromo-8-fluoro-2-methylquinoline (CAS 1259519-95-3)
- 1-(2-Bromo-4-fluorophenyl)cyclopropanecarbonitrile (CAS 1314663-80-3)
- 4-Bromo-7-fluoro-2-methylquinoline (CAS 1070879-48-9)
- 1-(3-Bromo-5-fluorophenyl)cyclopropane-1-carbonitrile (CAS 1314709-94-8)
- Benzyl 4-(((3,4-dimethoxyphenyl)amino)methyl)-4-hydroxypiperidine-1-carboxylate (CAS 1353877-97-0)
- 5-phenyl-1-pentanol (CAS 10521-91-2)
- (S)-tert-Butyl (1-(1H-imidazol-2-yl)-2-methylpropyl)carbamate (CAS 172729-99-6)
- 2-[3-(trifluoromethyl)benzoyl]cyclohexan-1-one (CAS 444077-10-5)
- 3-Methyl-3-(4-methylphenyl)propiophenone (CAS 898768-45-1)
- 1-(2-Methoxyphenyl)-1H-pyrazol-3-amine (CAS 90840-02-1)
- 3-(4-(tert-Butyl)phenyl)propanoic acid (CAS 1208-64-6)
- Erlotinib Impurity 28 (CAS CATO-C4X-106928)
- 1-(4-Fluorophenyl)propane-1,2-dione (CAS 10557-24-1)
- Semaglutide Impurity 138 (CAS CATO-C4X-2226138)
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