(S)-Ethyl 4,4-difluoro-1-((r)-1-phenylethyl)piperidine-2-carboxylate CAS 1072344-63-8
| CAS No. | 1072344-63-8 |
| Molecular Formula | C16H21F2NO2 |
| Molecular Weight | 297.34 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
(S)-Ethyl 4,4-difluoro-1-((r)-1-phenylethyl)piperidine-2-carboxylate (CAS 1072344-63-8) is a high-purity analytical reference standard with the molecular formula C16H21F2NO2 and a molecular weight of 297.34 g/mol.
Based on its molecular formula C16H21F2NO2, (S)-Ethyl 4,4-difluoro-1-((r)-1-phenylethyl)piperidine-2-carboxylate contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 297.34 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), (S)-Ethyl 4,4-difluoro-1-((r)-1-phenylethyl)piperidine-2-carboxylate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H21F2NO2 |
| Molecular Weight | 297.34 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Recommended Standards
- Upadacitinib Impurity 91 (CAS CATO-C4X-240591)
- Tert-butyl 3-fluoro-4-((methylsulfonyl)oxy)piperidine-1-carboxylate (CAS 1207176-25-7)
- Piroxicam Impurity 20 (CAS CATO-C4X-173320)
- N-Phenyl-2-(pyrimidin-2-ylamino)thiazole-4-carboxamide (CAS 1251559-53-1)
- 2,5-Bis(4-(pyridin-4-yl)phenyl)thiazolo[5,4-d]thiazole (CAS 2230607-18-6)
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- 1-(5-Chloropentyl)-1h-imidazole (CAS 1097807-13-0)
- 4-Amino-2,3,6-trichlorophenol (CAS 64981-10-8)
- 2-(Difluoromethoxy)-5-methoxyphenol (CAS 1261825-52-8)
- (2,4-Dimethyl-phenyl)-methanethiol (CAS 90535-40-3)
- Gabapentine Impurity 12 (CAS 6700-95-4)
- Sulindac EP Impurity D (CAS 134439-52-4)
- Semaglutide impurity 60 (CAS CATO-C4X-222660)
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