Pyrroloquinoline Impurity 4 CAS 107575-60-0
| CAS No. | 107575-60-0 |
| Molecular Formula | C12H14N2O3 |
| Molecular Weight | 234.25 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Pyrroloquinoline Impurity 4.
As a process- or degradation-related impurity, Pyrroloquinoline Impurity 4 (CAS 107575-60-0, C12H14N2O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C12H14N2O3, Pyrroloquinoline Impurity 4 contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 234.25 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H14N2O3 |
| Molecular Weight | 234.25 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Nitrogen Atoms | 2 |
Related Pyrroloquinoline Standards
Recommended Standards
- Mephenytoin Impurity 4 (CAS 61837-65-8)
- Lasmiditan Impurity 74 (CAS CATO-C4X-247874)
- (S) -4-Hydroxymephenytoin (CAS 82695-93-0)
- Lamivudine-13c,15n2,d2 (CAS CATO-CCAD303867)
- Sulbactam Impurity 33 (CAS CATO-C4X-175633)
- Sofosbuvir Impurity 83 (CAS CATO-C4X-105283)
- Orforglipron impurity 118 (CAS CATO-C4X-3234118)
- Relugolix Impurity 114 (CAS 89179-64-6)
- (S)-2-Amino-N-((3R,4S,5S)-1-((S)-2-((1R,2R)-3-(((1S,2R)-1-hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidin-1-yl)-3-methoxy-5-methyl-1-oxoheptan-4-yl)-N,3-dimethylbutanamide (CAS 1438852-38-0)
- 2,5,7-Trimethylbenzo[b]thiophene-3-sulfonamide (CAS 1384429-49-5)
- 2-Methyl-4,5-dihydropyrazolo[1,5-a]quinoxaline (CAS 193151-04-1)
- Quinolin-8-yl (2,4,5-trichlorophenyl)carbamate (CAS 14577-75-4)
- 4-(1H-Pyrazol-1-yl)pyridine-2-carboxylic acid (CAS 1152523-86-8)
- Semaglutide impurity 91 (CAS CATO-C4X-222691)
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