5-Methyl-2-(2,2,2-trifluoroacetamido)thiophene-3-carboxylic acid CAS 1082186-04-6

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 5-Methyl-2-(2,2,2-trifluoroacetamido)thiophene-3-carboxylic acid.

5-Methyl-2-(2,2,2-trifluoroacetamido)thiophene-3-carboxylic acid (CAS 1082186-04-6), molecular formula C8H6F3NO3S and molecular weight 253.20 g/mol, is a CATO reference standard with documented purity and traceability.

The molecular framework of 5-Methyl-2-(2,2,2-trifluoroacetamido)thiophene-3-carboxylic acid (C8H6F3NO3S) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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