Sulfadiazine EP Impurity A CAS 109-12-6
| CAS No. | 109-12-6 |
| Molecular Formula | C4H5N3 |
| Molecular Weight | 95.10 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Sulfadiazine EP Impurity A is closely related to a nitrile group in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Sulfadiazine EP Impurity A (CAS 109-12-6, C4H5N3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Sulfadiazine EP Impurity A (C4H5N3) is characterized by a nitrile group. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Sulfadiazine EP Impurity A meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C4H5N3 |
| Molecular Weight | 95.10 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 3 |
Related Sulfadiazine Standards
- Sulfadiazine lmpurity 5 (CAS CATO-C4X-150415)
- Sulfadiazine (CAS 68-35-9)
- Sulfadiazine-D4 (CAS 1020719-78-1)
- Sulfadiazine-13C6 (CAS 1189426-16-1)
- Sulfadiazine lmpurity 4 (CAS CATO-C4X-150414)
- Sulfadiazine Impurity 1 (4-Hydroxy Sulfadiazine) (CAS 56305-66-9)
- Sodium Sulfadiazine (CAS 547-32-0)
- Sulfadiazine lmpurity 6 (CAS CATO-C4X-150416)
Recommended Standards
- Glucosamine sulfate Impurity 13 (CAS 1003-29-8)
- Iminodiacetonitrile (CAS 628-87-5)
- Furosemide Impurity 56 (CAS 4439-57-0)
- 2-Aminopyrazine (CAS 5049-61-6)
- Dopamine Impurity 17 (CAS 1129-53-9)
- Eravacycline impurity 41 (CAS CATO-C4X-293841)
- Lornoxicam Impurity 43 (CAS CATO-C4X-201643)
- Benzoyl(4-formyl-3-isopropyl-1,2,3-oxadiazol-3-ium-5-yl)amide (CAS 1103492-09-6)
- (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-methylhex-5-enoic acid (CAS 288617-72-1)
- Isopropyl 3,3-difluoro-1-(hydroxymethyl)cyclobutanecarboxylate (CAS 1645565-02-1)
- 1-Cyclopropyl-1-(3,5-difluorophenyl)ethan-1-ol (CAS 1378859-91-6)
- Methyl (S)-4-methyl-1,2,3,4-tetrahydroisoquinoline-7-carboxylate hydrochloride (CAS 2758015-49-3)
- 5-Fluoro-2-methylbenzoyl Chloride (CAS 21900-39-0)
- Semaglutide impurity 36 (CAS CATO-C4X-222636)
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