Norfloxacin Impurity 22 CAS 109142-49-6
| CAS No. | 109142-49-6 |
| Molecular Formula | C16H18FN3O4 |
| Molecular Weight | 335.33 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 335.33 g/mol gives Norfloxacin Impurity 22 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Norfloxacin Impurity 22 (CAS 109142-49-6), a pharmacopoeial impurity reference standard (molecular formula C16H18FN3O4, MW 335.33 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Norfloxacin Impurity 22 (C16H18FN3O4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 335.33 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Norfloxacin Impurity 22 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H18FN3O4 |
| Molecular Weight | 335.33 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Norfloxacin Standards
- Norfloxacin Piperazinyl-1-Oxide (CAS 1796931-70-8)
- Norfloxacin EP Impurity E (CAS 75001-85-3)
- Norfloxacin EP Impurity F (CAS 67681-84-9)
- Norfloxacin Impurity 65 (CAS CATO-C4X-146865)
- Norfloxacin Impurity 50 (CAS CATO-C4X-146850)
- Norfloxacin Impurity 31 (CAS CATO-C4X-146831)
- Norfloxacin Impurity 39 (CAS CATO-C4X-146839)
- Norfloxacin Impurity 67 (CAS CATO-C4X-146867)
Recommended Standards
- Levofloxacin Impurity 89 (CAS CATO-C4X-137189)
- Lomefloxacin Impurity 19 (CAS CATO-C4X-207319)
- Levofloxacin Impurity 61 (CAS CATO-C4X-137161)
- 4-Bromo-2-chloro-5-fluoroiodobenzene (CAS 1000572-73-5)
- Pentoxifylline Impurity 30 (CAS CATO-C4X-172830)
- Mivacurium chloride Impurity 24 (CAS 188956-91-4)
- Regadenoson Impurity 38 (CAS CATO-C4X-198538)
- 3-methyl-2-(1-methyl-1H-pyrazol-5-yl)butan-1-amine (CAS 1522545-56-7)
- 4-(4-Ethylphenyl)-2-methylbut-3-yn-2-ol (CAS 155105-68-3)
- 4-(Methoxymethyl)aniline (CAS 80936-82-9)
- Bicalutamide Impurity 32 (CAS CATO-C4X-101332)
- Terephthaloyl chloride-d<SUB>4</SUB> (CAS 129775-07-1)
- 3-Chloro-4,5-difluoropyridine (CAS 851178-98-8)
- Integrin Binding Peptide trifluoroacetate salt (CAS 278792-07-7)
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