Norfloxacin EP Impurity E CAS 75001-85-3
| CAS No. | 75001-85-3 |
| Molecular Formula | C16H18ClN3O3 |
| Molecular Weight | 335.79 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Norfloxacin EP Impurity E (CAS 75001-85-3), a pharmacopoeial impurity reference standard (molecular formula C16H18ClN3O3, MW 335.79 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Norfloxacin EP Impurity E is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 335.79 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C16H18ClN3O3 |
| Molecular Weight | 335.79 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1978 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Norfloxacin Standards
- Norfloxacin EP Impurity F (CAS 67681-84-9)
- Norfloxacin Impurity 65 (CAS CATO-C4X-146865)
- Norfloxacin Piperazinyl-1-Oxide (CAS 1796931-70-8)
- Norfloxacin Impurity 22 (CAS 109142-49-6)
- Norfloxacin Impurity 50 (CAS CATO-C4X-146850)
- Norfloxacin Impurity 31 (CAS CATO-C4X-146831)
- Norfloxacin Impurity 39 (CAS CATO-C4X-146839)
- Norfloxacin Impurity 67 (CAS CATO-C4X-146867)
Recommended Standards
- N-benzyl-3-(5-chlorobenzo[d]oxazol-2-yl)pyridin-2-amine (CAS 339102-05-5)
- N-{5H,6H-benzo[h]quinazolin-2-yl}-3-chlorobenzamide (CAS 306979-37-3)
- N-(4-chlorophenyl)-2-(2,4-dioxo-1,3-diazaspiro[4.5]Decan-3-yl)acetamide (CAS 731781-51-4)
- Azasetron Impurity 4 (CAS CATO-C4X-28684)
- Mitoxantrone Impurity 26 (CAS CATO-C4X-103426)
- Alectinib Impurity 84 (CAS CATO-C4X-283684)
- Ropinirole EP Impurity C HCl (CAS 145570-92-9)
- 2-Ethoxy-N-((3-methyl-1,2,4-oxadiazol-5-yl)methyl)-1-naphthamide (CAS 1235284-04-4)
- 2,5-Dichloro-3-methylacetophenone (CAS 1804896-15-8)
- 2-(Dibenzylamino)acetohydrazide (CAS 81807-26-3)
- Physostigmine Hemisulfate (CAS 64-47-1)
- 4-chloro-6-methyl-1H-pyrazolo[4,3-c]pyridine (CAS 1159828-70-2)
- 1-Cyclohexyl-N-((5-fluorothiophen-2-yl)methyl)-1H-pyrazol-5-amine hydrochloride (CAS 1856086-05-9)
- Semaglutide impurity 49 (CAS CATO-C4X-222649)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com