1-[4-[[4-[(3,4-Dichloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]oxy]-1-piperidinyl]-2-propen-1-one CAS 1092364-38-9
| CAS No. | 1092364-38-9 |
| Molecular Formula | C23H21Cl2FN4O3 |
| Molecular Weight | 491.34 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures 1-[4-[[4-[(3,4-Dichloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]oxy]-1-piperidinyl]-2-propen-1-one under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
1-[4-[[4-[(3,4-Dichloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]oxy]-1-piperidinyl]-2-propen-1-one (CAS 1092364-38-9) is a high-purity analytical reference standard with the molecular formula C23H21Cl2FN4O3 and a molecular weight of 491.34 g/mol.
The molecular framework of 1-[4-[[4-[(3,4-Dichloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]oxy]-1-piperidinyl]-2-propen-1-one (C23H21Cl2FN4O3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C23H21Cl2FN4O3 |
| Molecular Weight | 491.34 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related Dichloro Standards
- 2-((N-(2,4-dichloro-5-(2-methoxyethoxy)phenyl)-4-methoxyphenyl)sulfonamido)-N,N-dimethylacetamide (CAS 400085-62-3)
- N-(3,4-Dichloro-2-fluorophenyl)-6-methoxy-7-(((3aR,5r,6aS)-2-methyloctahydrocyclopenta[c]pyrrol-5-yl)methoxy)quinazolin-4-amine (CAS 781613-23-8)
- (Z)-3-(2,4-Dichloro-3-methoxy-5-((Z)-4-((4-methoxybenzyl)amino)-4-oxobut-2-en-2-yl)phenyl)-N-ethylbut-2-enamide (CAS 1956426-45-1)
- 2,6-Dichloro-N-(4-chloro-3-(2-(dimethylamino)ethoxy)phenyl)-4-(trifluoromethyl)benzenesulfonamide (CAS 345892-71-9)
- 3,4-dichloro-4'-(1,3-dioxolan-2-yl)benzophenone (CAS 898760-86-6)
- 2,3-Dichloro-N-(1-(3-methoxybenzyl)-5,6-dimethyl-1H-benzo[d]imidazol-4-yl)benzenesulfonamide (CAS 338955-25-2)
- 2,4-Dichloro-N-(1-(3-methoxybenzyl)-5,6-dimethyl-1H-benzo[d]imidazol-4-yl)benzenesulfonamide (CAS 866038-57-5)
- 2,5-Dichloro-N-(1-(4-methoxybenzyl)-5,6-dimethyl-1H-benzo[d]imidazol-4-yl)benzenesulfonamide (CAS 338955-02-5)
Recommended Standards
- 4-(4-(4-Bromophenyl)-5-((3-(trifluoromethyl)benzyl)thio)-4H-1,2,4-triazol-3-yl)pyridine (CAS 477332-92-6)
- 2-(4-Ethoxyphenyl)-4-oxo-4H-chromen-3-yl 2,5-dichlorobenzene-1-sulfonate (CAS 298217-82-0)
- 5-(Trifluoromethyl)-2,3-bis[3-(trifluoromethyl)benzoyl]pyridine (CAS 338770-69-7)
- 4-(2,4-Dichlorophenyl)-2-(4-methylpiperazin-1-yl)-6-[3-(trifluoromethyl)phenyl]pyridine-3-carbonitrile (CAS 303984-86-3)
- 1-(1-Ethoxyethoxy)-2-methylbutane (CAS 13602-09-0)
- Methyl 4-chloro-5-nitro-1H-pyrrole-2-carboxylate (CAS 1706433-18-2)
- 3-Fluoro-4'-hydroxy-[1,1'-biphenyl]-2-carboxylic acid (CAS 1261932-02-8)
- 8-Bromo-3-methoxyquinolin-2(1H)-one (CAS 1434103-24-8)
- Montelukast EP Impurity A (CAS 220927-27-5)
- 2-Bromo-1-(2-(sec-butylamino)-1H-imidazol-4-yl)ethanone (CAS 88723-50-6)
- 5-[1-(dimethylamino)propyl]-4-[2-(morpholin-4-yl)ethyl]-4H-1,2,4-triazole-3-thiol (CAS 879362-32-0)
- Methyl cis-7,10,13,16,19-Docosapentaenoate (CAS 108698-02-8)
- 7-AVCA Impurity 1 (CAS CATO-C4X-23161)
- Semaglutide impurity 89 (CAS CATO-C4X-222689)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com