4-(2,4-Dichlorophenyl)-2-(4-methylpiperazin-1-yl)-6-[3-(trifluoromethyl)phenyl]pyridine-3-carbonitrile CAS 303984-86-3
| CAS No. | 303984-86-3 |
| Molecular Formula | C24H19Cl2F3N4 |
| Molecular Weight | 491.34 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4-(2,4-Dichlorophenyl)-2-(4-methylpiperazin-1-yl)-6-[3-(trifluoromethyl)phenyl]pyridine-3-carbonitrile (CAS 303984-86-3), molecular formula C24H19Cl2F3N4 and molecular weight 491.34 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4-(2,4-Dichlorophenyl)-2-(4-methylpiperazin-1-yl)-6-[3-(trifluoromethyl)phenyl]pyridine-3-carbonitrile (C24H19Cl2F3N4) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-(2,4-Dichlorophenyl)-2-(4-methylpiperazin-1-yl)-6-[3-(trifluoromethyl)phenyl]pyridine-3-carbonitrile meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C24H19Cl2F3N4 |
| Molecular Weight | 491.34 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related Dichlorophenyl Standards
- (2E)-2-{4-[5-(2,4-dichlorophenyl)furan-2-yl]-1,3-thiazol-2-yl}-3-[3-(trifluoromethyl)phenyl]prop-2-enenitrile (CAS 338978-48-6)
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Recommended Standards
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- Vandetanib N-Hydroxymethyl Analog (CAS 910298-61-2)
- 2-Fluorobenzyl 4-amino-1,2,5-oxadiazole-3-carboxylate (CAS 340828-48-0)
- 2-Fluorobenzyl 1-(2-fluorobenzyl)piperidine-3-carboxylate (CAS 1261233-00-4)
- 4-Bromo-2-fluoro-N-(2-(isopropyl(methyl)amino)ethyl)benzamide (CAS 1311897-92-3)
- 5-[4-(trifluoromethyl)phenyl]-4h-1,2,4-triazol-3-amine (CAS 178556-79-1)
- Benzofuran-5-carbothioamide (CAS 499770-74-0)
- 8-Bromo-2-((tert-butoxycarbonyl)amino)-3H-benzo[b]azepine-4-carboxylic acid (CAS 1226791-81-6)
- 1-(2-Chloropyridin-4-yl)ethan-1-amine (CAS 1060811-99-5)
- Flurbiprofen Impurity 144 (CAS CATO-C4X-1444144)
- 63181-98-6 D-Glucitol, 1-deoxy-1-(((ethenylphenyl)methyl)methylamino)-, polymer with diethenylbenzene Divinylbenzene, vinylbenzyl-N-methylglucamine polymer (CAS 63181-98-6)
- [3-31]-Semaglutide D (CAS C152H230N42O47)
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