6-Chloro-3-(2-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazine CAS 1094354-48-9
| CAS No. | 1094354-48-9 |
| Molecular Formula | C11H6ClFN4 |
| Molecular Weight | 248.64 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
6-Chloro-3-(2-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazine (CAS 1094354-48-9) is a high-purity analytical reference standard with the molecular formula C11H6ClFN4 and a molecular weight of 248.64 g/mol.
The molecular framework of 6-Chloro-3-(2-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazine (C11H6ClFN4) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), 6-Chloro-3-(2-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H6ClFN4 |
| Molecular Weight | 248.64 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related Chloro Standards
- 6-Chloro-3-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazine (CAS 1094260-22-6)
- 6-Chloro-3-(3-fluorophenyl)[1,2,4]triazolo[4,3-b]pyridazine (CAS 1094425-19-0)
- 3-Chloro-6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazine (CAS 1116743-29-3)
- 2-(2-Chloro-4-fluorophenoxy)nicotinonitrile (CAS 1183594-45-7)
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- 5-Chloro-2-(2-fluorophenyl)oxazolo[5,4-b]pyridine (CAS 126921-80-0)
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Recommended Standards
- 2-(Chloromethyl)-1-methyl-5-(trifluoromethyl)-1H-benzo[d]imidazole (CAS 942034-99-3)
- 3-Oxo-2H,3H,4H-pyrido[3,2-b][1,4]oxazine-7-sulfonyl chloride (CAS 1116135-67-1)
- 2-(4-Chlorophenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile (CAS 20932-04-1)
- 2-(3-Chlorophenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile (CAS 338982-39-1)
- 3-Amino-4-(3-chlorophenyl)-1-ethylazetidin-2-one (CAS 1706651-65-1)
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- Semaglutide Impurity 13 (CAS CATO-C4X-222613)
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