Methadone Hydrochloride CAS 1095-90-5
| CAS No. | 1095-90-5 |
| Molecular Formula | C21H27NO |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Methadone Hydrochloride (C21H27NOHCl) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Methadone Hydrochloride (CAS 1095-90-5) is a high-purity analytical reference standard with the molecular formula C21H27NOHCl and a molecular weight of 345.91 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Methadone Hydrochloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H27NO HCl |
| Molecular Weight | 345.91 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Methadone Standards
- Methadone Impurity 6 (CAS 117449-78-2)
- Methadone Impurity A (CAS 14474-54-5)
- (S)-Methadone hydrochloride (CAS 15284-15-8)
- Methadone Hydrochloride - Impurity D (Hydrochloride Salt) (CAS 5341-49-1)
- (R)-Methadone hydrochloride (CAS 5967-73-7)
- (±)-Methadone-D3 (CAS 60263-63-0)
- Methadone Impurity C (CAS 6293-01-2)
- rac Methadone-d3 Hydrochloride (100ug/mL in Methanol) (CAS 65566-72-5)
Recommended Standards
- N-tert-Butoxycarbonyl 3,5-Diiodotyramine (CAS 788824-51-1)
- n-Ethylpent-1-yn-3-amine (CAS 1488880-22-3)
- 2-Amino-2-(1-methyl-3-(thiophen-2-yl)-1h-1,2,4-triazol-5-yl)ethan-1-ol (CAS 1341814-88-7)
- N2-(2-methoxyethyl)-N2-methylpyridine-2,3-diamine (CAS 1303988-17-1)
- N-methyl-1-(1-methyl-3-(thiophen-2-yl)-1H-pyrazol-4-yl)methanamine (CAS 1226160-18-4)
- 1-(2-(Thiophen-3-yl)ethyl)-1h-1,2,4-triazol-3-amine (CAS 1340419-56-8)
- Rabeprazole impurity 51 (CAS CATO-C4X-112151)
- Cyclopropyl(4-fluoro-3-methylphenyl)methanone (CAS 1017193-22-4)
- 1-(Furo[2,3-c]pyridin-7-yl)piperidine-4-carboxylic acid (CAS 1707735-66-7)
- Tirzepatide Impurity 23 X TFA Salt (CAS CATO-C4X-324023)
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