1-(2,2,2-Trifluoroacetyl)piperidine-3-carboxylic acid CAS 1099017-20-5
| CAS No. | 1099017-20-5 |
| Molecular Formula | C8H10F3NO3 |
| Molecular Weight | 225.17 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 1-(2,2,2-Trifluoroacetyl)piperidine-3-carboxylic acid is closely related to an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
1-(2,2,2-Trifluoroacetyl)piperidine-3-carboxylic acid (CAS 1099017-20-5) is a high-purity analytical reference standard with the molecular formula C8H10F3NO3 and a molecular weight of 225.17 g/mol.
The molecular framework of 1-(2,2,2-Trifluoroacetyl)piperidine-3-carboxylic acid (C8H10F3NO3) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H10F3NO3 |
| Molecular Weight | 225.17 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Trifluoroacetyl Standards
- 2-(1-(2,2,2-Trifluoroacetyl)pyrrolidin-2-yl)acetic acid (CAS 1247229-06-6)
- 1-(2,2,2-Trifluoroacetyl)piperidine-4-carboxylic acid (CAS 126501-70-0)
- 3-Methyl-1-(2,2,2-trifluoroacetyl)pyrrolidine-3-carboxylic acid (CAS 1341068-64-1)
- 2-Methyl-1-(2,2,2-trifluoroacetyl)pyrrolidine-2-carboxylic acid (CAS 1341106-97-5)
- 2-Methyl-1-(2,2,2-trifluoroacetyl)pyrrolidine-3-carboxylic acid (CAS 1508488-17-2)
- (R)-1-(2,2,2-Trifluoroacetyl)piperidine-2-carboxylic acid (CAS 1567892-21-0)
- 5-(Trifluoroacetyl)thiophene-2-carboxylic Acid (CAS 929028-43-3)
- Ethyl 2-(2,2,2-trifluoroacetyl)pentanoate (CAS 10556-91-9)
Recommended Standards
- (E)-3-(4,4,4-Trifluoro-3-oxobut-1-en-1-yl)benzonitrile (CAS 101048-56-0)
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- 3,5-Dinitro-O-Toluamide (CAS 148-01-6)
- 3-(n-Cyclopropyl-2,2,2-trifluoroacetamido)propanoic acid (CAS 1178418-17-1)
- Octaethyl (benzene-1,2,4,5-tetrayltetrakis(methylene))tetrakis(phosphonate) (CAS 136455-49-7)
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- Palmitoyl Tripeptide-1 HCl (CAS 2757690-14-3)
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