Docetaxel Impurity 36 CAS 110258-92-9
| CAS No. | 110258-92-9 |
| Molecular Formula | C38H39Cl9O16 |
| Molecular Weight | 1070.78 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 1070.78 g/mol gives Docetaxel Impurity 36 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Docetaxel Impurity 36 (CAS 110258-92-9, C38H39Cl9O16) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Docetaxel Impurity 36 (C38H39Cl9O16) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, a polycyclic aromatic system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Docetaxel Impurity 36 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C38H39Cl9O16 |
| Molecular Weight | 1070.78 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | Cl-containing |
Related Docetaxel Standards
- Docetaxel Impurity 85 (CAS 1095547-79-7)
- Docetaxel Impurity 56 (CAS CATO-C4X-161956)
- Docetaxel Impurity 57 (CAS CATO-C4X-161957)
- Docetaxel Impurity 59 (CAS CATO-C4X-161959)
- Docetaxel Impurity 61 (CAS CATO-C4X-161961)
- Docetaxel Impurity 74 (CAS CATO-C4X-161974)
- Docetaxel Impurity 75 (CAS CATO-C4X-161975)
- Docetaxel Impurity 34 (CAS 1095547-96-8)
Recommended Standards
- 3,3'-(2,6-Bis(trimethylstannyl)benzo[1,2-b:4,5-b']dithiophene-4,8-diyl)bis(9-(2-ethylhexyl)-9H-carbazole) (CAS 2213459-50-6)
- Cefpirome Impurity 30 (CAS CATO-C4X-120730)
- Temsirolimus Acetonide (CAS 162635-03-2)
- Cefpirome Impurity 42 (CAS CATO-C4X-120742)
- Pemetrexed EP Impurity B (CAS 1802552-04-0)
- Bortezomib Impurity 20 (CAS 862894-96-0)
- Peramivir Impurity 69 (CAS CATO-C4X-183369)
- 2-(Difluoromethyl)-5-hydroxypyridine-4-carboxamide (CAS 1803690-78-9)
- 3'-(3,4-Dichlorophenyl)-1-[(2,4-dichlorophenyl)methyl]-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-2,4'-dione (CAS 338406-10-3)
- methyl imidazo[1,5-a]pyridine-8-carboxylate (CAS 151509-02-3)
- 3-(4-Methoxyphenyl)pyrazin-2(1H)-one (CAS 88066-91-5)
- 2-Amino-1-(4-fluoro-3-(trifluoromethyl)phenyl)ethanone 4-methylbenzenesulfonate (CAS 1082951-17-4)
- Clonidine Impurity 1 (CAS 21709-18-2)
- Semaglutide impurity 56 (CAS CATO-C4X-222656)
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